942130-26-9

Basic information

• Product Name: Boc-Trp(Tos)-OMe
• Synonyms: Boc-Trp(Tos)-OMe
• CAS NO: 942130-26-9
• Molecular Weight: 472.562
• Mol File: 942130-26-9.mol

Chemical Properties

• CAS DataBase Reference: Boc-Trp(Tos)-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Trp(Tos)-OMe(942130-26-9)
• EPA Substance Registry System: Boc-Trp(Tos)-OMe(942130-26-9)

Safety Data

• Hazardous Substances Data: 942130-26-9(Hazardous Substances Data)

Upstream product

• 141215-69-2 N-(tert-butyloxycarbonyl)-2-(3-indolyl)glycin methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Facile N-tert-butoxycarbonylation of amines using La(NO3)3·6H2O as a mild and efficient catalyst under solvent-free conditions

Facile N-tert-butoxycarbonylation of amines is described by the treatment of various primary, secondary, benzylic and aryl amines with di-tert-butyl dicarbonate in the presence of catalytic amounts of La(NO3)3·6H2O under solvent-free conditions at room temperature to afford N-tert-butylcarbamates in excellent yields.

Mild reductive cleavage of tryptophan and histidine side-chain protecting groups

The activation potentials of the p-toluenesulfonyl and benzoyl groups as determined by cyclic voltammetry when they are linked to indole or imidazole are less negative than when these groups are linked to aliphatic amines. This makes them most suitable for side-chain protection of tryptophan and histidine, as it allows mild selective cleavage not only by controlled-potential electrolysis but also by chemical reduction using either magnesium in anhydrous methanol or mercury-activated aluminum.