942145-27-9

Basic information

• Product Name: CarbaMic acid, N-[(1S)-1-(aMinoMethyl)-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-N-Methyl-, 1,1-diMethylethyl ester
• Synonyms: CarbaMic acid, N-[(1S)-1-(aMinoMethyl)-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-N-Methyl-, 1,1-diMethylethyl ester
• CAS NO: 942145-27-9
• Molecular Formula: C₁₄H₂₈N₂O₃
• Molecular Weight: 272.38372
• Mol File: 942145-27-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 370.2°C at 760 mmHg
• Flash Point: 177.7°C
• Appearance: /
• Density: 1.026g/cm³
• Vapor Pressure: 1.13E-05mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: 2-8°C
• CAS DataBase Reference: CarbaMic acid, N-[(1S)-1-(aMinoMethyl)-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-N-Methyl-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: CarbaMic acid, N-[(1S)-1-(aMinoMethyl)-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-N-Methyl-, 1,1-diMethylethyl ester(942145-27-9)
• EPA Substance Registry System: CarbaMic acid, N-[(1S)-1-(aMinoMethyl)-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-N-Methyl-, 1,1-diMethylethyl ester(942145-27-9)

Safety Data

• Hazardous Substances Data: 942145-27-9(Hazardous Substances Data)

Usage

General Description

CarbaMic acid, N-[(1S)-1-(aMinoMethyl)-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-N-Methyl-, 1,1-diMethylethyl ester is a chemical compound also known as fosphetamine. It is a prodrug of amphetamine, a central nervous system stimulant commonly used to treat attention deficit hyperactivity disorder and narcolepsy. Fosphetamine is metabolized in the body to release d-amphetamine, which acts as a norepinephrine-dopamine releasing agent. CarbaMic acid, N-[(1S)-1-(aMinoMethyl)-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-N-Methyl-, 1,1-diMethylethyl ester has the potential to be abused and is subject to regulations and control due to its stimulating effects and potential for dependence.

InChI:InChI=1/C14H28N2O3/c1-14(2,3)19-13(17)16(4)12(9-15)8-11-6-5-7-18-10-11/h11-12H,5-10,15H2,1-4H3/t11-,12+/m1/s1

Upstream product

• 1093865-02-1 1,1-dimethylethyl methyl{2-({[(phenylmethyl)oxy]carbonyl}amino)-1-[(3R)-tetrahydro-2H-pyran-3-ylmethyl]ethyl}carbamate 
• 1013937-77-3 (R)-2-(3-chloro-propyl)-N-((1S,2S)-1-hydroxy-1-phenyl-propan-2-yl)-N-methyl-pent-4-enamide 
• 1093865-64-5 1,1-dimethylethyl {2-amino-1-[(3R)-tetrahydro-2H-pyran-3-ylmethyl]ethyl}methylcarbamate 
• 1013937-76-2 5-chloro-N-((1S,2S)-1-hydroxy-1-phenyl-propan-2-yl)-N-methyl-pentanamide 
• 1013937-78-4 (R)-2-(3-chloro-propyl)-pent-4-en-1-ol 
• 1013937-83-1 N-(2-((R)-tetrahydro-2H-pyran-3-yl)-eth-(E)-ylidene)methanamine 
• 1013937-79-5 (R)-3-allyl-tetrahydro-2H-pyran 
• 1013937-81-9 (R)-2-(tetrahydro-2H-pyran-3-yl)-acetaldehyde 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 153080-81-0 (2S,4R)-1-tert-butyl 4-allyl-2-ethoxycarbonyl-5-oxopyrrolidine-1-carboxylate 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 942145-24-6 tert-butyl (S)-1-azido-3-((R)-tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamate 
• 942145-23-5 (S)-2-(tert-butoxycarbonylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propyl 4-methylbenzenesulfonate 
• 942144-43-6 tert-butyl (S)-1-hydroxy-3-((R)-tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamate 

Downstream Products

• 1093865-45-2 methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-[{[(1,1-dimethylethyl)oxy]carbonyl}(methyl)amino]-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate 
• 1093865-51-0 [2-{3-[((S)-2-methoxycarbonylamino-ethoxy)-phenyl-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester 
• 1093865-57-6 [2-{3-[((S)-2-methoxycarbonylamino-ethoxy)-m-tolyl-methyl]-benzoylamino}-1-((R)-tetrahydropyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester 
• 1093865-63-4 [2-{3-[(3-chloro-5-fluoro-phenyl)-((S)-2-methoxycarbonylamino-ethoxy)-methyl]-benzoylamino}-1-((R)-tetrahydro-pyran-3-ylmethyl)-ethyl]-methyl-carbamic acid tert-butyl ester 
• 1013937-63-7 methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate trifluoroacetate 
• 1093864-75-5 methyl {2-[((R)-(3-chlorophenyl){3-[({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}amino)carbonyl]phenyl}methyl)oxy]ethyl}carbamate 

Relevant articles and documents

Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility

Structure guided optimization of a series of nonpeptidic alkyl amine renin inhibitors allowed the rational incorporation of additional polar functionality. Replacement of the cyclohexylmethyl group occupying the S1 pocket with a (R)-(tetrahydropyran-3-yl)

PROCESS FOR THE PREPARATION OF RENIN INHIBITORS

Disclosed is a process for the preparation of a tetrahydropyran-di-amine represented by Structural Formula (I): wherein R1 is H or alkyl and E is H or an amine protecting group.