942199-41-9Relevant academic research and scientific papers
Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists
Gillman, Kevin W.,Higgins, Mendi A.,Poindexter, Graham S.,Browning, Marc,Clarke, Wendy J.,Flowers, Sharon,Grace Jr., James E.,Hogan, John B.,McGovern, Rachel T.,Iben, Lawrence G.,Mattson, Gail K.,Ortiz, Astrid,Rassnick, Stefanie,Russell, John W.,Antal-Zimanyi, Ildiko
, p. 5517 - 5526 (2007/10/03)
A series of novel 5,5-diphenylimidazolones was synthesized and evaluated for activity against the human neuropeptide Y5 receptor. The 3-pyridyl analog 46 demonstrated an IC50 of 8.3 nM with a favorable pharmacokinetic profile in rats, but was i
