942206-01-1

Basic information

• Product Name: 5-BROMO-2'-CHLORO-[3,4']-BIPYRIDINE
• Synonyms: 5-BROMO-2'-CHLORO-[3,4']-BIPYRIDINE
• CAS NO: 942206-01-1
• Molecular Formula: C₁₀H₆BrClN₂
• Molecular Weight: 269.52504
• Product Categories: Heterocyclic Compounds
• Mol File: 942206-01-1.mol

Chemical Properties

• Boiling Point: 351.6°C at 760 mmHg
• Flash Point: 166.4°C
• Appearance: /
• Density: 1.591g/cm³
• Vapor Pressure: 8.26E-05mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: 5-BROMO-2'-CHLORO-[3,4']-BIPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2'-CHLORO-[3,4']-BIPYRIDINE(942206-01-1)
• EPA Substance Registry System: 5-BROMO-2'-CHLORO-[3,4']-BIPYRIDINE(942206-01-1)

Safety Data

• Hazardous Substances Data: 942206-01-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H6BrClN2/c11-9-3-8(5-13-6-9)7-1-2-14-10(12)4-7/h1-6H

Upstream product

• 233770-01-9 3-bromo-5-iodopyridine 
• 458532-96-2 2-chloropyridine-4-boronic acid 

Downstream Products

• 1354758-67-0 2'-(2-fluoro-phenyl)-5-(2-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-[3,4']bipyridinyl 
• 1354758-60-3 2'-(2-fluoro-phenyl)-5-quinolin-3-yl-[3,4']bipyridinyl 
• 1354758-96-5 2'-(2-fluoro-phenyl)-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-[3,4']bipyridinyl 
• 1354758-50-1 2-{4-[2'-(2-fluoro-phenyl)-[3,4']bipyridinyl-5-yl]-pyrazol-1-yl}-ethanol 
• 1354758-75-0 2'-(2,5-difluoro-phenyl)-5-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-[3,4']bipyridinyl hydrochloride 
• 1354758-90-9 4-{4-[2'-(2,5-difluoro-phenyl)-[3,4']bipyridinyl-5-yl]-pyrazol-1-yl}-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. Th e present invention provides a nicotinamide derivative represented by the follo wing formula (I) (wherein R 1 represents a halogen atom; R 2 represents a C 1-12 alkyl group, a C 2-12 alkenyl group, a C 2-12 alkynyl group, a C 3-8 cycloalkyl g roup, an aryl group, an ar-C 1-6 alkyl group or a heterocyclic group, each opti onally having at least one substituent; R 3 represents an aryl group or a hetero cyclic group each optionally having at least one substituent; and R 4 and R 5 e ach independently represent a hydrogen atom; and R 2 and R 4 may form a cyc lic amino group optionally having at least one substituent together with the ni trogen atom to which they bind) or a salt thereof, and a pharmaceutical comp osition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

BIPYRIDYL DERIVATIVES

The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to

BIPYRIDYL DERIVATIVES USEFUL FOR THE TREATMENT OF KINASE - INDUCED DISEASES

The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to