942227-31-8Relevant academic research and scientific papers
Quinoline-carboxylic acids are potent inhibitors that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins
Zhu, Yun-Fei,Wang, Xiao-Chuan,Connors, Patrick,Wilcoxen, Keith,Gao, Yinghong,Gross, Raymond,Strack, Nathalie,Gross, Timothy,McCarthy, James R.,Xie, Qiu,Ling, Nicholas,Chen, Chen
, p. 1931 - 1934 (2003)
4-Benzylquinolines 5, based on a series of isoquinolines 1, were prepared and tested as inhibitors of the IGF/IGFBP-3 complex based on their ability to displace IGF-I from its binding to IGF-binding protein-3. SAR studies on the 6,7-dihydroxy moiety of the quinoline 5a showed that the catecol moiety could be replaced with other functional groups. Computational modeling of the 5a/mini-IGFBP-5 complex revealed the possible binding site of 5a on IGFBP-5.
