94224-49-4

Upstream product

• 91445-18-0 3-bromo-2-trimethylsilyl-1-propene 
• 55287-89-3 2-(trimethylsilyl)prop-2-en-1-ol 
• 94225-17-9 1-Cyclohexyl-3-trimethylsilanyl-but-3-en-1-one 
• 94224-45-0 1-Cyclohexyl-2-(2-trimethylsilanyl-oxiranyl)-ethanone 

Relevant academic research and scientific papers

Synthesis of 2-substituted-4-trimethylsilylfurans using 2,3-bis(trimethylsilyl)propene

2-Substituted-4-trimethylsilylfurans were prepared by treatment of the epoxycarbonyl compounds 3 with LDA or t-BuLi. 3a-j were obtained from the Lewis acid mediated reaction of 2,3-bis(trimethylsilyl)propene with acid chlorides and followed by epoxidation with MCPBA.

The reactivity of 3-bromo-2-trimethylsilyl-1-propene towards electrophiles. A short synthesis of 2-substituted-4-trimethylsilylfurans.

3-bromo-2-trimethylsilyl-1-propene 1c reacts with various electrophiles (aldehydes, a ketone, nitriles, terminal alkynes) in the presence of zinc to give functionnalized vinylsilanes.A three steps synthesis of 2-substituted-4-trimethylsilylfurans from 1c