942277-36-3Relevant academic research and scientific papers
Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitors VI. A series of new derivatives containing N,S- and N,SO2-spiro acetal scaffolds
Saitoh, Fumihiko,Nishida, Hidemitsu,Mukaihira, Takafumi,Kosuga, Naoto,Ohkouchi, Munetaka,Matsusue, Tomokazu,Shiromizu, Ikuya,Hosaka, Yoshitaka,Matsumoto, Miwa,Yamamoto, Ichiro
, p. 317 - 323 (2007/10/03)
In the course of development of factor Xa (FXa) inhibitors, we have found unique compounds containing an N,O- and an N,N-spiro acetal structure. It appeared that the difference in overall conformation due to the N,X-spiro acetal structure might be importa
