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Usage

Uses

Used in Pharmaceutical Industry:
PI 828 is used as a research tool for studying the role of PI3K enzymes in various cellular processes and their involvement in diseases such as cancer. Its enhanced potency against different PI3K isoforms makes it a valuable compound for investigating the specific functions and inhibition of these enzymes.
Used in Drug Development:
PI 828 can be used as a starting point for the development of new drugs targeting the PI3K family of enzymes, which play a crucial role in cell growth, survival, and metabolism. By inhibiting these enzymes, PI 828 may have potential therapeutic applications in treating various diseases, including cancer.
Used in Drug Delivery Systems:
The immobilization of PI 828 on an epoxy-containing solid surface allows for the development of drug delivery systems that can specifically target and release the compound to the desired cellular proteins. This can improve the efficacy and bioavailability of PI 828, as well as reduce potential side effects by limiting its interaction with non-target proteins.
Used in Binding Studies:
PI 828's interaction with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα, makes it a useful compound for studying the binding and interaction of these proteins with PI3K inhibitors. This can provide valuable insights into the mechanisms of action of PI 828 and other similar compounds, as well as help identify potential off-target effects and improve the design of future drugs.

Biological Activity

PI 3-Kinase inhibitor (IC 50 values are 0.098, 0.183, 0.227 and 1.967 μ M for p110 β , p110 α , p110 δ and p110 γ respectively) that displays higher potency than LY 294002 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride). Can be immobilized onto a solid phase.

InChI:InChI=1/C19H18N2O3/c20-14-6-4-13(5-7-14)15-2-1-3-16-17(22)12-18(24-19(15)16)21-8-10-23-11-9-21/h1-7,12H,8-11,20H2