942318-57-2

Upstream product

• 63069-48-7 p-chloro-o-iodoaniline 

Downstream Products

• 942318-58-3 ethyl 1-(4-chloro-2-iodophenyl)-1H-1,2,3-triazole-4-carboxylate 
• 1417819-68-1 1-azido-4-chloro-2-(phenylethynyl)benzene 
• 1453188-89-0 3-(2-azido-5-chlorophenyl)-1-phenylprop-2-yn-1-yl acetate 
• 1453188-88-9 3-(2-azido-5-chlorophenyl)-1-phenylprop-2-yn-1-yl methyl carbonate 
• 1453188-78-7 6-chloro-2-phenylquinolin-4-yl acetate 

Relevant academic research and scientific papers

Synthesis of Azidoanilines by the Buchwald-Hartwig Amination

We report a Buchwald-Hartwig amination compatible with azido functionality. Treatment of azidoaryl iodides and amines with fourth-generation Buchwald precatalyst coordinated by CPhos and sodium tert-butoxide in 1,4-dioxane at 50 °C afforded the corresponding azidoanilines while leaving the azido groups intact. The method showed a broad substrate scope and was applicable to the synthesis of diazido compounds as photoaffinity probe candidates of pharmaceutical amines and multiazido platform molecules.

Synthesis of indole-fused heteroacenes by cascade cyclisation involving rhodium(ii)-catalysed intramolecular C-H amination

Heteroacenes are potentially important materials for organic electronics and their syntheses are of topical interest. Herein we report the development of a catalytic, redox-neutral reaction for the synthesis of the 5,10-dihydroindolo[3,2-b]indole class of

Unprecedented synthesis of 1,2,3-triazolo-cinnolinone via Sonogashira coupling and intramolecular cyclization

An unprecedented copper mediated one-pot sequential synthesis of 1,2,3-triazolo cinnolinone derivatives from 2-halo-phenyl triazoles and terminal alkynes has been reported. Under the optimized reaction conditions, a broad range of substituted triazoles and alkynes were found to participate in this transformation, thus affording unknown 1,2,3-triazolo cinnolinone derivatives in moderate to excellent yields. This method proceeds through sequential C-C coupling followed by an annulation cascade sequence in the same vessel under atmospheric air as the sole oxidant, thus representing a simple, efficient and atom economical approach for the synthesis of aza-cinnolinones.

Cu(I)-catalyzed cascade intramolecular cyclization of 2-propynol phenyl azides and diarylphosphine oxides for the synthesis of bisphosphorylated indole derivatives

The [Cu(OTf)]2·C6H6 catalyzed cascade intermolecular addition–intramolecular cyclization reaction of easily prepared 2-propynol phenyl azides and diarylphosphine oxides was developed. This novel reaction leads to simultane

FACTOR XIa INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.

Cyclization of Alkyne-Azide with Isonitrile/CO via Self-Relay Rhodium Catalysis

A self-relay rhodium(I)-catalyzed cyclization of alkyne-azides with two σ-donor/π-acceptor ligands (isonitriles and CO) to form sequentially multiple-fused heterocycle systems via tandem nitrene transformation and aza-Pauson-Khand cyclization has been dev

FACTOR XIA INHIBITORS

The present invention provides a compound of Formula I(The chemical formula should be inserted here.) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

Facile and efficient synthesis of [1,4]oxazino[3,2-b]indoles and 1H-pyrazino[2,3-b]indoles through gold-catalyzed cascade cyclization of (azido)ynamides

[1,4]Oxazino[3,2-b]indoles as well as 1H-pyrazino[2,3-b]indoles are constructed in good to excellent yields via gold-catalyzed cascade cyclization of (azido)ynamides. The use of readily available starting materials, a simple procedure and mild reaction co

Tandem synthesis of benzo[b]carbazoles and their photoluminescent properties

5 H-Benzo[b]carbazoles were prepared through a tandem reaction between 2-ethynyl-N-triphenylphosphoranylidene anilines and α-diazoketones through ketenimine intermediates in moderate-to-good yields. By using this approach, benzo[b]benzo[5,6]indolo[3,2-h]carbazoles, fluoreno[9,1-ab]carbazoles, and fluoreno[9,1-ab]fluoreno[1′,9′:5,6,7]indolo[3,2-h]carbazoles were constructed in one pot. Moreover, the resulting products emitted light within the range 410-521a nm, with quantum yields of up to 62 %. Lord of the rings: A series of benzo[b]carbazoles was synthesized through a tandem Wolff-rearrangement/aza-Wittig-reaction/biradical-ketenimine-cyclization/1, 5-H-shift process. The products emitted intense light with high emission quantum yields (see scheme). Copyright

DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS

Disclosed are novel dipeptide analogs compounds of Formula (I), (II) or (III) or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, which are inhibitors of factor XIa and/or plasma kallikrein, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of thrombotic diseases.