94239-04-0

Basic information

• Product Name: 2-Fluoro-6-trifluoromethylpyridine
• Synonyms: 2-FLUORO-6-(TRIFLUOROMETHYL)PYRIDINE;2-FLUORO-6-RIFLUOROMETHYLPYRIDINE;2-Trifluoromethyl-6-fluoropyridine;2-Fluoro-6-(trifluoromethyl)py;2-Fluooro-6-trifluoroMethylpyridine;Pyridine, 2-fluoro-6-(trifluoroMethyl)-;2-Fluoro-6-(trifluoromethyl)pyridine,98%;-Fluoro-6-(trifluoromethyl)pyridine
• CAS NO: 94239-04-0
• Molecular Formula: C6H3F4N
• Molecular Weight: 165.09
• EINECS: 428-100-3
• Product Categories: blocks;FluoroCompounds;Pyridines;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridine;Pyridines derivates;API intermediates
• Mol File: 94239-04-0.mol

Chemical Properties

• Boiling Point: 121.6 °C at 760 mmHg
• Flash Point: 27.3 °C
• Appearance: Cloroless to light yellow liquid
• Density: 1.371 g/cm³
• Vapor Pressure: 0.0351mmHg at 25°C
• Refractive Index: 1.4010-1.4050
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -5.11±0.12(Predicted)
• Water Solubility: 1.9g/L at 25℃
• CAS DataBase Reference: 2-Fluoro-6-trifluoromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-6-trifluoromethylpyridine(94239-04-0)
• EPA Substance Registry System: 2-Fluoro-6-trifluoromethylpyridine(94239-04-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 20/21/22-36/37/38-36-25
• Safety Statements: 26-36/37/39-45
• RIDADR: 1993
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 94239-04-0(Hazardous Substances Data)

Usage

Chemical Properties

Cloroless to light yellow liquid

InChI:InChI=1/C6H6F3N3/c7-6(8,9)4-2-1-3-5(11-4)12-10/h1-3H,10H2,(H,11,12)

Upstream product

• 1929-82-4 nitrapyrin 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 

Downstream Products

• 957345-34-5 2-fluoro-3-iodo-6-(trifluoromethyl)pyridine 
• 1620690-75-6 C₂₃H₂₈F₃N₃O₃ 
• 1624604-11-0 (4S,6S)-4-(2-fluoro-5-((6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 957345-37-8 2-fluoro-4-iodo-6-(trifluoromethyl)pyridine 
• 1143464-61-2 4-tert-butyl-2-(6-(trifluoromethyl)pyridin-2-yloxy)benzoic acid 
• 1143464-57-6 4-tert-butyl-N-(3-(methylsulfonyl)phenyl)-2-(6-(trifluoromethyl)pyridin-2-yloxy)benzamide 
• 944900-24-7 6-(trifluoromethyl)pyridine-2-sulfonyl chloride 

Relevant articles and documents

Synthetic method of 2-fluorine-6-tirfluoromethylpyridine

The invention belongs to the field of pesticide intermediate synthesis, and more specially relates to a synthetic method of 2-fluorine-6-tirfluoromethylpyridine. According to the synthetic method, 2-chloro-6-tirchloromethylpyridine and anhydrous hydrogen fluoride are taken as raw materials, under the effect of a catalyst, reaction is carried out at 70 to 150 DEG C 2 to 4.0MPa so as to obtain a 2-fluorine-6-tirfluoromethylpyridine crude product, and purifying is carried out so as to obtain 2-fluorine-6-tirfluoromethylpyridine; the catalyst is mixed antimony halide. The preparation method is simple; the raw materials are cheap and easily available; technology route is simple; no solid waste is generated; product yield is higher than 95%; product content is higher than 99%; waste gas hydrogenfluoride and hydrogen chloride are absorbed by an alkaline solution; and almost no environment pollution is caused.

Continuous preparation method for 2-fluoro-6-trifluoromethyl pyridine

The invention discloses a continuous preparation method for 2-fluoro-6-trifluoromethyl pyridine, and belongs to the field of fine chemical intermediate synthesis processes. The continuous preparation method comprises the following steps: adding a bedding material into a reactor; starting a circulating pump; rising temperature by heat conducting oil; when the pressure of the reactor reaches a regulated value, starting a feeding pump; continuously adding hydrogen fluoride and 2-chloro-6-trichloromethyl pyridine into the reactor according to a ratio; reacting the two raw materials in the reactor to generate crude 2-fluoro-6-trifluoromethyl pyridine; extracting the crude 2-fluoro-6-trifluoromethyl pyridine through an outlet of the circulating pump; cooling the crude 2-fluoro-6-trifluoromethyl pyridine, and collecting the cooled 2-fluoro-6-trifluoromethyl pyridine in a receiving tank. A qualified 2-fluoro-6-trifluoromethyl pyridine product can be obtained by performing flash evaporation and rectification processing on the crude product which is extracted from the bottom of the reactor; hydrogen chloride and hydrogen fluoride gases which are exhausted from the top of the reactor enter an alkali absorption system and are treated in a centralized manner. The continuous preparation method for the 2-fluoro-6-trifluoromethyl pyridine is an effective method for improving the project production capacity and reducing the project production cost.

PROCESS FOR PRODUCING 2-FLUORO-6-(TRIFLUOROMETHYL)PYRIDINE COMPOUNDS

The present invention relates to an industrially feasible and economically viable process for the preparation of 2-fluoro-6-(trifluoromethyl)pyridine compounds of Formula (I). The process comprises fluorination of one or more pyridine compounds of Formula (II) with a fluorinating agent and isolating 2-fluoro-6-(trifluoromethylpyridine compound of Formula (I) obtained, which are useful as intermediates in the synthesis of many agrochemical and pharmaceutical products.