94239-04-0Relevant articles and documents
Synthetic method of 2-fluorine-6-tirfluoromethylpyridine
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Paragraph 0008; 0020-0033, (2019/08/12)
The invention belongs to the field of pesticide intermediate synthesis, and more specially relates to a synthetic method of 2-fluorine-6-tirfluoromethylpyridine. According to the synthetic method, 2-chloro-6-tirchloromethylpyridine and anhydrous hydrogen fluoride are taken as raw materials, under the effect of a catalyst, reaction is carried out at 70 to 150 DEG C 2 to 4.0MPa so as to obtain a 2-fluorine-6-tirfluoromethylpyridine crude product, and purifying is carried out so as to obtain 2-fluorine-6-tirfluoromethylpyridine; the catalyst is mixed antimony halide. The preparation method is simple; the raw materials are cheap and easily available; technology route is simple; no solid waste is generated; product yield is higher than 95%; product content is higher than 99%; waste gas hydrogenfluoride and hydrogen chloride are absorbed by an alkaline solution; and almost no environment pollution is caused.
PROCESS FOR PRODUCING 2-FLUORO-6-(TRIFLUOROMETHYL)PYRIDINE COMPOUNDS
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Page/Page column 11, (2016/01/16)
The present invention relates to an industrially feasible and economically viable process for the preparation of 2-fluoro-6-(trifluoromethyl)pyridine compounds of Formula (I). The process comprises fluorination of one or more pyridine compounds of Formula (II) with a fluorinating agent and isolating 2-fluoro-6-(trifluoromethylpyridine compound of Formula (I) obtained, which are useful as intermediates in the synthesis of many agrochemical and pharmaceutical products.