94239-06-2

Usage

Uses

Used in Organic Synthesis:
2-Hydrazino-6-(trifluoromethyl)pyridine is used as a reagent in organic synthesis for its ability to act as a versatile building block, facilitating the preparation of a variety of pharmaceuticals and agrochemicals.
Used in Heterocyclic Compounds Synthesis:
It is utilized in the synthesis of heterocyclic compounds, which are important in the development of new materials and have significant applications in various fields.
Used in Medicinal Chemistry Research:
2-Hydrazino-6-(trifluoromethyl)pyridine is employed as a building block in medicinal chemistry research, contributing to the discovery and development of new therapeutic agents.
Used in Fluorinated Compounds Preparation:
2-HYDRAZINO-6-(TRIFLUOROMETHYL)PYRIDINE is also used in the preparation of various fluorinated compounds, capitalizing on the unique chemical properties imparted by the trifluoromethyl group, which is of interest in the field of organic synthesis and chemical research.

InChI:InChI=1/C8H6FN3S/c9-6-3-1-5(2-4-6)7-11-12-8(10)13-7/h1-4H,(H2,10,12)

Upstream product

• 39890-95-4 2-chloro-6-trifluoromethylpyridine 
• 143812-60-6 6-trifluoromethyltetrazolo<1,5-a>pyridine 
• 1513-65-1 2,6-difluoro pyridine 

Downstream Products

• 1431142-68-5 C₂₇H₂₁Cl₂F₆N₇O₂ 
• 1427301-07-2 C₂₂H₁₃Cl₂F₆N₇ 

Relevant academic research and scientific papers

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists

Previously disclosed C6 amido and benzimidazole dihydropyrazolopyrimidines were potent and selective blockers of IKur current. Syntheses and SAR for C6 triazolo and imidazo dihydropyrazolopyrimidines series are described. Trifluoromethylcyclohexyl N(1) triazole, compound 51, was identified as a potent and selective Kv1.5 inhibitor with an acceptable PK and liability profile.

2-Pyridylnitrene-1,3-diazacyclohepta-1,2,4,6-tetraene rearrangements in the trifluoromethyl-2-pyridyl azide series

Photolysis of Ar matrix isolated trifluoromethyl-substituted 2-pyridyl azides/tetrazolo[1,5-a]pyridines at 12-18 K causes rapid and mostly clean conversion to the corresponding 1,3-diazacyclohepta-1,2,4,6-tetraenes (4D, 5D, 5,6D, and 4,6D) absorbing near 2000 cm-1 in the IR. In the latter case, the intermediate 3,5-bis(trifluoromethyl)-2-pyridylnitrene (4,6N) was observed by both ESR and IR spectroscopy and converted to the diazacycloheptatetraene 4,6D in the course of 90 min of UV irradiation. The 2-pyridylnitrenes were generally observable by ESR spectroscopy (D/hc ~ 1.05-1.10; E/hc ~ 0.0 cm-1) following both photochemical and thermal (FVP) generation from the 2-azidopyridines. Irradiation of the Ar matrix isolated mixtures of nitrenes and diazacycloheptatetraenes also caused development of weak carbene transitions (D/hc ~ 0.40-0.45; E/hc ~ 0.006 cm-1) in the ESR spectra.

Trifluoromethyl-substituted Dehydrodiazepines and Cyanopyrroles from Azido-/Tetrazolo-pyridines

1,2-Didehydro-1,3-diazepines 4D, 5D, 4,6D and 5,6D are identified as unique products of both photolysis and thermolysis of azido-/tetrazolo-pyridines; the ultimate thermolysis products are trifluoromethylpyrrolecarbonitriles (7-9, 11-13 and 16-18).

Novel (1H-1,2,3-triazol-1-yl)pyridines

Pyridine ring substituted (1H-1,2,3-triazol-1-yl)pyridines were prepared and found to have insecticidal utility. 2-Chloro-6-(1H-1,2,3-triazol-1-yl)pyridine, for example, was prepared from 2-azio-6-chloropyridine and methyl propiolate by sequential condensation, hydrolysis, and decarboxylation and found to control aster leafhoppers.