942413-08-3Relevant academic research and scientific papers
Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists
Yang, Lihu,Butora, Gabor,Jiao, Richard X.,Pasternak, Alex,Zhou, Changyou,Parsons, William H.,Mills, Sander G.,Vicario, Pasquale P.,Ayala, Julia M.,Cascieri, Margaret A.,MacCoss, Malcolm
, p. 2609 - 2611 (2007)
Introduction of ring restrictions to a linear aminobutyramide CC chemokine receptor 2 (CCR2) antagonist lead (2) led to the discovery of a 1,3-disubstituted cyclopentane scaffold with enhanced hCCR2 receptor binding and antagonist activity. (1S,3R)-N-[3,5
