942416-44-6

Basic information

• Product Name: C₁₃H₁₀ClN₃S
• Synonyms: C₁₃H₁₀ClN₃S
• CAS NO: 942416-44-6
• Molecular Weight: 275.761
• Mol File: 942416-44-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₀ClN₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₀ClN₃S(942416-44-6)
• EPA Substance Registry System: C₁₃H₁₀ClN₃S(942416-44-6)

Safety Data

• Hazardous Substances Data: 942416-44-6(Hazardous Substances Data)

Upstream product

• 529508-57-4 5-(bromomethyl)-4-chloropyrrolo[2,1-f][1,2,4]triazine 
• 108-98-5 thiophenol 

Downstream Products

• 529508-59-6 [1-(3-fluoro-benzyl)-1H-indazol-5-yl]-(5-phenylsulfanylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine 
• 859205-97-3 [3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-(5-phenylsulfanylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine 
• 529508-53-0 (5-benzenesulfinylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-[1-(3-fluoro-benzyl)-1H-indazol-5-yl]-amine 
• 529508-60-9 (5-[1,4]Diazepan-1-ylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-[1-(3-fluoro-benzyl)-1H-indazol-5-yl]-amine 
• 529509-27-1 1-{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-piperidine-4-carboxylic acid methyl ester 
• 529509-43-1 1-{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-piperidine-4-carboxylic acid 

Relevant articles and documents

Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases

Novel C-5 aminomethyl pyrrolotriazines were prepared and optimized for dual EGFR and HER2 protein tyrosine kinase inhibition. The homopiperazine, 1p, emerged as a key lead and it showed promising oral efficacy in EGFR and dual EGFR/HER2 driven human tumor xenograft models. It is hypothesized that the C-5 homopiperazine side chain binds in the ribose-phosphate portion of the ATP binding pocket.