94250-56-3

Upstream product

• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 100-51-6 benzyl alcohol 
• 84794-38-7 5-(1-hydroxy-2-methylpropylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1373129-24-8 benzyl 4-methylpenta-2,3-dienote 
• 563-80-4 3-methyl-butan-2-one 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 

Downstream Products

• 188526-08-1 2-diazo-4-methyl-3-oxo-pentanoic acid benzyl ester 
• 805242-33-5 2-benzylidene-4-methyl-3-oxo-pentanoic acid benzyl ester 
• 871107-17-4 4-methyl-3-oxo-2-[(Z)-1-phenyl-methylidene]pentanoic acid benzyl ester 
• 1003612-89-2 benzyl 2-amino-4-isopropylselenazole-5-carboxylate 
• 1003612-88-1 benzyl 2-amino-4-isopropylthiazole-5-carboxylate 
• 912998-70-0 2-isopropyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid 
• 912998-86-8 2-isopropyl-4,5-diphenyl-1H-pyrrole-3-carboxylic acid benzyl ester 
• 912998-87-9 4-methyl-3-oxo-2-(2-oxo-1,2-diphenyl-ethyl)-pentanoic acid benzyl ester 
• 147118-36-3 N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide 
• 94250-70-1 4,4-dimethyl-2-(hydroxymethylene)-3-<3-methyl-2-oxobutyl>cyclohexanone 
• 188526-10-5 5-isopropyl-2-oxo-[1,3]dioxole-4-carboxylic acid benzyl ester 
• 188526-09-2 2-hydroxy-4-methyl-3-oxo-pentanoic acid benzyl ester 
• 188525-84-0 5-isopropyl-2-oxo-[1,3]dioxole-4-carboxylic acid 
• 188525-85-1 4-(hydroxymethyl)-5-(propan-2-yl)-2H-1,3-dioxol-2-one 

Relevant academic research and scientific papers

Stereocontrolled synthesis of rosuvastatin calcium via iodine chloride-induced intramolecular cyclization

A novel, stereoselective approach towards rosuvastatin calcium from the known (S)-homoallylic alcohol has been developed. The synthesis is highlighted by a regio- and stereocontrolled ICl-induced intramolecular cyclization of chiral homoallylic carbonate to deliver the C6-formyl statin side chain with a syn-1,3-diol moiety. An improved synthesis of the rosuvastatin pyrimidine core moiety is also included. Moreover, this methodology is useful in the asymmetric synthesis of structural variants of statins such as pitavastatin calcium and atorvastatin calcium and their related analogs.

Oxone-promoted hydration of electron-deficient allenic esters and ketones into 1,3-dicarbonyl compounds

Abstract A novel and mild protocol for the hydration of electron-deficient allenic esters and ketones into various 1,3-dicarbonyl compounds is described. The hydration of allenes promoted by oxone in DMF afforded the corresponding products in moderate to good yields. This work features the employment of only a catalytic amount of inexpensive and nontoxic solid reagent oxone (2KHSO5·KHSO4·K2SO4), avoiding the utility of toxic metals or traditional Br?nsted acids, in a green version of viewpoint. A possible reaction mechanism for this transformation is also primarily proposed.

Bismuth(III) chloride-catalyzed highly efficient transesterification of β-keto esters

Bismuth(III) chloride was found to be an efficient catalyst for the transesterification of a variety of β-keto esters with a wide range of alcohols to afford transesterified products in good to high yields in short reaction times (see Table). Copyright

Substituted 6-phenylnicotinic acids and their use

The present application relates to novel substituted 6-phenylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, in particular dyslipidaemias, arteriosclerosis and heart failure.

PYRROLE COMPOUNDS AND USES THEREOF

Pyrrole compounds, compositions and methods are provided for the treatment, prevention, or amelioration of neurodegenerative diseases, cardiovascular diseases, proliferative diseases and visual disorders. In particular, pyrrole compounds, compositions and methods for the treatment of stroke are disclosed herein.

Microwave-assisted solution-phase synthesis of 1,4,5-trisubstituted pyrazoles

A small parallel library of 1,4,5-trisubstituted pyrazoles was prepared in solution using a three-step procedure starting from Meldrum acid. The Meldrum acid was acylated with different acyl chlorides and the products opened with different alcohols and amines to give substituted β-keto esters and β-keto amines. Further reaction with N,N-dimethylformamide dimethylacetal and the final cyclisation were effectively carried out under microwave irradiation. Scavenger resins were employed exclusively in the first step, whereas use of microwaves allowed complete conversion of the starting materials in the other two steps. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

A general synthesis of dioxolenone prodrug moieties

A general method for the synthesis of dioxolenone prodrug moieties from appropriately substituted β-ketoesters is described. This novel and versatile sequence allows for the synthesis of alkyl- or aryl-substituted dioxolenone alcohols 8 or bromides 9. Coupling of the bromides 9 to prepare bis-dioxolenone phosphonate prodrug esters is also presented.

Annulation of α-Formyl α,β-Unsaturated Ketones by a Michael Addition-Cyclization Sequence. A Versatile Synthesis of Alicyclic Six-Membered Rings.

The potential generality of the annulation sequence shown in Scheme II (10 -> 11 -> 12 -> 13 -> 14/15) has been examined in model systems.Dehydrogenation of α-formylcyclohexanones 11a-d with 1 equiv of DDQ rapidly produces α,β-unsaturated α-formyl ketones