94250-56-3Relevant articles and documents
Stereocontrolled synthesis of rosuvastatin calcium via iodine chloride-induced intramolecular cyclization
Xiong, Fangjun,Wang, Haifeng,Yan, Lingjie,Han, Sheng,Tao, Yuan,Wu, Yan,Chen, Fener
, p. 1363 - 1369 (2016/02/03)
A novel, stereoselective approach towards rosuvastatin calcium from the known (S)-homoallylic alcohol has been developed. The synthesis is highlighted by a regio- and stereocontrolled ICl-induced intramolecular cyclization of chiral homoallylic carbonate to deliver the C6-formyl statin side chain with a syn-1,3-diol moiety. An improved synthesis of the rosuvastatin pyrimidine core moiety is also included. Moreover, this methodology is useful in the asymmetric synthesis of structural variants of statins such as pitavastatin calcium and atorvastatin calcium and their related analogs.
Bismuth(III) chloride-catalyzed highly efficient transesterification of β-keto esters
Sabitha, Gowravaram,Srinivas, Rangavajjula,Gopal, Peddabuddi,Bhikshapathi,Yadav, Jhillu Singh
experimental part, p. 119 - 121 (2011/03/17)
Bismuth(III) chloride was found to be an efficient catalyst for the transesterification of a variety of β-keto esters with a wide range of alcohols to afford transesterified products in good to high yields in short reaction times (see Table). Copyright
PYRROLE COMPOUNDS AND USES THEREOF
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, (2010/11/24)
Pyrrole compounds, compositions and methods are provided for the treatment, prevention, or amelioration of neurodegenerative diseases, cardiovascular diseases, proliferative diseases and visual disorders. In particular, pyrrole compounds, compositions and methods for the treatment of stroke are disclosed herein.