942511-67-3

Upstream product

• 41667-95-2 5,6-dichloronicotinic acid 
• 106-47-8 4-chloro-aniline 
• 951771-57-6 5-chloro-6-(4-chloro-phenylamino)-nicotinic acid methyl ester 

Downstream Products

• 1072929-01-1 [5-(1H-benzoimidazol-2-yl)-3-chloro-pyridin-2-yl]-(4-chloro-phenyl)-amine 
• 1072929-11-3 [3-chloro-5-(5-fluoro-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-chloro-phenyl)-amine 
• 1072929-10-2 [3-chloro-5-(5-fluoro-1-methyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-chloro-phenyl)-amine 
• 1072929-00-0 [3-chloro-5-(1-methyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-chloro-phenyl)-amine 
• 1072929-03-3 3-chloro-N-(4-chlorophenyl)-5-(1-propyl-1H-benzo[d]imidazol-2-yl)pyridin-2-amine 

Relevant academic research and scientific papers

Benzimidazoles as potent and orally active mGlu5 receptor antagonists with an improved pk profile

A focused chemical optimization effort of compound 1 based on metabolite elucidation is described, resulting in 15i, a highly potent and selective mGlu5 receptor antagonist with an improved pharmacokinetic profile compared to 1. Characterization of 15i in

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity

High throughput screening led to the identification of nicotinamide derivative 2 as a structurally novel mGluR5 antagonist. Optimization of the modular scaffold led to the discovery of 16m, a compound with high affinity for mGluR5 and excellent selectivit

Organic compounds

The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the formula (I): in which the substitutents are as defined in claim 1 and salts, solvates, hydrates and N-oxides thereof.

NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5

The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the Formula (I): in which the substitutents are as defined in claim 1 and and salts, solvates, hydrates and N- oxides thereof.

NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention relates to novel nicotinic acid derivatives, of formula (I), wherein the substituents are defined in the specification, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.