942589-45-9Relevant academic research and scientific papers
Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles
Court, John J.,Poisson, Carl,Ardzinski, Andrzej,Bilimoria, Darius,Chan, Laval,Chandupatla, Kishan,Chauret, Nathalie,Collier, Philip N.,Das, Sanjoy Kumar,Denis, Francois,Dorsch, Warren,Iyer, Ganesh,Lauffer, David,L'Heureux, Lucille,Li, Pan,Luisi, Brian S.,Mani, Nagraj,Nanthakumar, Suganthi,Nicolas, Olivier,Rao, B. Govinda,Ronkin, Steven,Selliah, Subajini,Shawgo, Rebecca S.,Tang, Qing,Waal, Nathan D.,Yannopoulos, Constantin G.,Green, Jeremy
, p. 6293 - 6302 (2016/07/26)
The hepatitis C viral proteins NS3/4A protease, NS5B polymerase, and NS5A are clinically validated targets for direct-acting antiviral therapies. The NS5B polymerase may be inhibited directly through the action of nucleosides or nucleotide analogues or al
2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS
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Page/Page column 46-47, (2010/11/30)
Anti-viral agents of compounds of Formula (I) wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
3-CARBONYLAMINOTHIOPHENE-2-CARBOXYLIC ACIDS AS HEPATITIS C VIRUS INHIBITORS
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Page/Page column 32-33, (2009/03/07)
The present invention relates to novel 2-carboxy thiophene compounds of the formula (I): and salts thereof, to pharmaceutical compositions containing them and their use in medicine, as anti-viral agents. Specifically, the present invention relates to comp
ANTIVIRAL 2-CARBOXY-THIOPHENE COMPOUNDS
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Page/Page column 27, (2008/06/13)
Anti-viral agents of compounds of Formula (I) : wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
