942589-69-7

Upstream product

• 586-76-5 4-Bromobenzoic acid 
• 16867-03-1 2-amino-3-hydroxypyridine 
• 111852-42-7 2-(4-bromophenyl)oxazolo[4,5-b]pyridine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 942590-01-4 methyl 3-((1-methylethyl){[trans-4-(trifluoromethyl)cyclohexyl]carbonyl}amino)-5-(4-[1,3]oxazolo[4,5-b]pyridin-2-ylphenyl)-2-thiophenecarboxylate 

Relevant academic research and scientific papers

Irreversible BTK inhibitor with oxazolo [4, 5-b] pyridine structure and application of irreversible BTK inhibitor

The invention discloses a compound capable of irreversibly inhibiting the activity of protein tyrosine kinase (BTK), pharmaceutically available salts of the compound, a synthesis method of the compound and application of the compound in medicines for inhibiting BTK protein. In particular, compounds of Formula A are described. The compound disclosed by the invention has good BTK inhibitory activity, the water solubility is also improved, and the pharmacokinetic parameters of the compound are basically consistent with those of a positive drug ibrutinib on the market, so that the compound can be widely applied to preparation of pharmaceutical preparations for preventing or treating diseases caused by BTK abnormality.

2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS

Anti-viral agents of compounds of Formula (I) wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.

ANTIVIRAL 2-CARBOXY-THIOPHENE COMPOUNDS

Anti-viral agents of compounds of Formula (I) : wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.