942596-10-3Relevant academic research and scientific papers
Enantioselective Formation of CF3-Bearing All-Carbon Quaternary Stereocenters via C-H Functionalization of Methanol: Iridium Catalyzed Allene Hydrohydroxymethylation
Holmes, Michael,Nguyen, Khoa D.,Schwartz, Leyah A.,Luong, Tom,Krische, Michael J.
, p. 8114 - 8117 (2017)
Using an iridium catalyst modified by PhanePhos, CF3-allenes react with methanol to form branched products of hydrohydroxymethylation as single regioisomers with excellent levels of enantiomeric enrichment. This hydrogen autotransfer process enables catalytic enantioselective formation of acyclic CF3-bearing all-carbon quaternary stereocenters in the absence of stoichiometric metals or byproducts.
NOVEL COMPOUNDS, THEIR PREPARATION AND USE
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Page/Page column 156, (2008/06/13)
Novel compounds of the general formula (I), the use of these compounds as phar- maceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.
