942598-45-0

Upstream product

• 942598-42-7 (R)-1-((1S,Z)-2-{[(R)-N-methylphenylsulfonimidoyl]methylene}cyclopentyl)ethanol 
• 3019-71-4 Trichloroacetyl isocyanate 

Downstream Products

• 942598-47-2 (3aS,4R,11S,11aR)-4-methyl-11-((R)-N-methyl-S-phenylsulfonimidoyl)-2,3,3a,4,8,9,10,11-octahydrocyclopenta[d]pyrido[1,2-c][1,3]oxazin-6(1H)-one 
• 942598-57-4 (4R,4aS,7aR)-7a-(iodomethyl)-4-methylhexahydrocyclopenta-[d][1,3]oxazin-2(1H)-one 
• 1394013-23-0 ethyl phenylsulfinylcarbamate 

Relevant academic research and scientific papers

Sulfoximine-based modular enantioselective synthesis of azaspirocycles featuring sulfoximine displacement, dianion cycloalkylation, RCM and N-acyliminium ion formation

We describe a modular, enantioselective synthesis of functionalised azaspirocycles with a range of ring sizes. The synthesis exploits the special features of sulfoximines, including chirality, carbanion-stabilisation, nucleophilicity, and nucleofugacity.

Modular asymmetric synthesis of functionalized azaspirocycles based on the sulfoximine auxiliary

A modular asymmetric synthesis of the functionalized azaspirocycles 6 (m = 2, n = 1), 7 (m = 1, n = 2), 8 (m = n = 2), 12, 20, and 24 from the cyclic allylic sulfoximines 1 is described. The synthetic strategy is based on the stereoselective construction