942910-36-3Relevant academic research and scientific papers
Novel approach for chemotype hopping based on annotated databases of chemically feasible fragments and a prospective case study: New melanin concentrating hormone antagonists
Oyarzabal, Julen,Howe, Trevor,Alcazar, Jesús,Andrés, Jose Ignacio,Alvarez, Rosa M.,Dautzenberg, Frank,Iturrino, Laura,Martínez, Sonia,Van Der Linden, Ilse
experimental part, p. 2076 - 2089 (2009/12/31)
A novel strategy for chemotype hopping, based on annotated databases of chemically feasible fragments and their oriented functionalization, is presented. A three-dimensional (3D) similarity analysis of projectoriented functionalized scaffolds provides a p
NOVEL SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES
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Page/Page column 39, (2008/06/13)
The present invention concerns aryl and heteroaryl substituted pyrazinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-I activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereo chemically isomeric form thereof, an TV-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are usefull for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders ; obesity ; diabetes ; sexual disorders and neurological disorders.
