942916-95-2Relevant academic research and scientific papers
Discovery of a new series of Aurora inhibitors through truncation of GSK1070916
Medina, Jesus R.,Grant, Seth W.,Axten, Jeffrey M.,Miller, William H.,Donatelli, Carla A.,Hardwicke, Mary Ann,Oleykowski, Catherine A.,Liao, Qiaoyin,Plant, Ramona,Xiang, Hong
scheme or table, p. 2552 - 2555 (2010/07/05)
Novel Aurora inhibitors were identified truncating clinical candidate GSK1070916. Many of these truncated compounds retained potent activity against Aurora B with good antiproliferative activity. Mechanistic studies suggested that these compounds, dependi
AZAINDOLE INHIBITORS OF AURORA KINASES
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Page/Page column 64-65, (2008/06/13)
The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including s
