942939-99-3Relevant academic research and scientific papers
Hydrogen-bond-directed enantioselective decarboxylative mannich reaction of β-ketoacids with ketimines: Application to the synthesis of anti-HIV drug DPC 083
Yuan, Hai-Na,Wang, Shuai,Nie, Jing,Meng, Wei,Yao, Qingwei,Ma, Jun-An
supporting information, p. 3869 - 3873 (2013/05/08)
Key to success: The title reaction provides facile access to enantioenriched 3,4-dihydroquinazolin-2(1H)-ones containing a quaternary stereogenic center in high yields with excellent enantioselectivities. Subsequent transformations lead to the convenient preparation of the anti-HIV drug DPC 083 and N-fused polycyclic compounds without loss of enantiomeric excess.
