942999-78-2Relevant academic research and scientific papers
Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor
Birch, Alan M.,Birtles, Susan,Buckett, Linda K.,Kemmitt, Paul D.,Smith, Graham J.,Smith, Tim J. D.,Turnbull, Andrew V.,Wang, Steven J. Y.
experimental part, p. 1558 - 1568 (2010/01/07)
Inhibition of DGAT-1 is increasingly seen as an attractive mechanism with the potential for treatment of obesity and other elements of the metabolic syndrome. We report here a bicyclooctaneacetic acid derivative in the pyrimidinooxazine structural class o
PYRIMIDO- [4, 5-B] -OXAZINES FOR USE AS DGAT INHIBITORS
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Page/Page column 48-49, (2008/06/13)
Formula (I). Compounds of formula (I) or salts thereof, wherein A1, and R1 to R5 are as defined in the specification, are DGAT-1 inhibitors and are thereby useful in the treatment of, for example, obesity. Processes to make compounds of formula (I) are also described.
