943-73-7

Basic information

• Product Name: L-Homophenylalanine
• Synonyms: RARECHEM BK PT 0049;(S)-2-AMINO-4-PHENYLBUTANOIC ACID;(S)-(+)-2-AMINO-4-PHENYLBUTYRIC ACID;(S)-2-AMINO-4-PHENYLBUTYRIC ACID;(S)-HOMOPHENYLALANINE;(2S)-2-Amino-4-phenylbutyric acid;(S)-APBA;(+)-2-Amino-4-phenylbutyric acid,98%
• CAS NO: 943-73-7
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.22
• EINECS: 213-403-3
• Product Categories: Chiral Compounds;Phenylalanine analogs and other aromatic alpha amino acids;API intermediates;Homophenylalanine [Hph];Amino Acids 13C, 2H, 15N;Chiral Compound;Amino Acids;Amino Acids & Derivatives;Aromatics
• Mol File: 943-73-7.mol

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 311.75°C (rough estimate)
• Flash Point: 150.2 °C
• Appearance: white solid
• Density: 1.1248 (rough estimate)
• Refractive Index: 44 ° (C=1, 3mol/L HCl)
• Storage Temp.: Store at RT.
• Solubility: Soluble in dilute aqueous acid.
• CAS DataBase Reference: L-Homophenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: L-Homophenylalanine(943-73-7)
• EPA Substance Registry System: L-Homophenylalanine(943-73-7)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 943-73-7(Hazardous Substances Data)

Usage

References

Hwang, J. Y., et al. "Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway." Biotechnology & Bioengineering 102.5(2009):1323-9.
Ahmad, A. L., P. C. Oh, and S. R. Abd Shukor. "Sustainable biocatalytic synthesis of L-homophenylalanine as pharmaceutical drug precursor."Biotechnology Advances 27.3(2009):286-296.
https://www.alfa.com/en/catalog/H27295/

Description

L-Homophenylalanine is an amino acid derivative. It has been extensively used in the pharmaceutical industry as a precursor for production of angiotensin-converting enzyme (ACE) inhibitor: enalapril, delapril, quinapril and ramipril, which possesses significant clinical application in the management of hypertension and congestive heart failure (CHF). It acts as an anti-tumor reagent.

Definition

ChEBI: A non-proteinogenic L-alpha-amino acid that is an analogue of L-phenylalanine having a 2-phenylethyl rather than a benzyl side-chain.

Chemical Properties

White Solid

Uses

Antitumor agent.

InChI:InChI=1/C10H13NO2/c11-9(10(12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13)

Upstream product

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Downstream Products

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