94304-63-9Relevant academic research and scientific papers
A reinvestigation of reaction of 2-hydrazino-3-phenylquinoxaline with 1,3-diketones: Synthesis and characterization of regioisomeric 1-(3′-phenylquinoxalin-2′-yl)-3,5-disubstitutedpyrazoles and 1,2,4-triazolo[4,3-a]quinoxalines
Eakta,Aggarwal, Ranjana,Sumran, Garima
, p. 273 - 281 (2013/05/09)
A reinvestigation into the reaction of 2-hydrazino-3-phenylquinoxaline 1 with several 1,3-diketones 2a-g reveals that a mixture of regioisomeric 1-(3′-phenylquinoxalin-2′-yl)-3,5-disubstitutedpyrazoles 3a-g and 4a-e and 1-methyl-4-phenyl/methyl-1,2,4-triazolo[4,3-a]quinoxalines 5a,b is formed as reaction products rather than erroneously reported exclusive formation of triazole 5 in case of aryl alkyl-1,3-diketones or 1-(3′- phenylquinoxalin-2′-yl)-3-alkylpyrazoles 4 in case of dialkyl and diaryl-1,3-diketones. Structural elucidation of the regioisomeric pyrazoles has been established by the spectroscopic data (1H, 13C NMR, COSY experiments and HRMS) and minimum energy 3-D diagrams.
