94318-82-8

Basic information

• Product Name: 2-bromo-N-cyclohexylpropanamide
• Synonyms: 2-Bromo-N-cyclohexylpropanamide; Propanamide, 2-bromo-N-cyclohexyl-
• CAS NO: 94318-82-8
• Molecular Formula: C₉H₁₆BrNO
• Molecular Weight: 234.1334
• Mol File: 94318-82-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 343.725°C at 760 mmHg
• Flash Point: 161.679°C
• Density: 1.313g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: 2-bromo-N-cyclohexylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-cyclohexylpropanamide(94318-82-8)
• EPA Substance Registry System: 2-bromo-N-cyclohexylpropanamide(94318-82-8)

Safety Data

• Hazardous Substances Data: 94318-82-8(Hazardous Substances Data)

Upstream product

• 108-91-8 cyclohexylamine 
• 563-76-8 α-bromopropionyl bromide 
• 598-72-1 2-Bromopropionic acid 
• 535-11-5 Ethyl 2-bromopropionate 

Downstream Products

• 1400272-77-6 N-cyclohexyl-2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl-sulfanyl)propionamide 

Relevant articles and documents

Comparative conventional and microwave assisted synthesis of heterocyclic oxadiazole analogues having enzymatic inhibition potential

A comparative microwave assisted and conventional synthetic strategies were applied to synthesize heterocyclic 1,3,4-oxadiazole analogues as active anti-enzymatic agents. Green synthesis of compound 1 was achieved by stirring 4-methoxybenzenesulfonyl chloride (a) and ethyl piperidine-4-carboxylate (b). Compound 1 was converted into respective hydrazide (2) by hydrazine and then into 1,3,4-oxadiazole (3) by CS2 on reflux. The electrophiles, N-alkyl/aralkyl/aryl-2-bromopropanamides (6a–p) were synthesized and converted to N-alkyl/aralkyl/aryl-2-propanamide derivatives (7a–p) by reaction with 3 under green chemistry. Microwave assisted method was found to be effective relative to conventional method. 13C-NMR, 1H-NMR and IR techniques were availed to corroborate structures of synthesized compounds and then subjected to screening against lipoxygenase (LOX), α-glucosidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. A number of compounds presented better potential against these enzymes. The most active compounds against LOX and α-glucosidase enzymes were subjected to molecular docking study to explore their interactions with the active sites of the enzymes.

Switchable Smiles Rearrangement for Enantioselective O-Aryl Amination

Asymmetric assembly of atropisomeric anilines from abundant and readily available precursors is one of the most challenging but valuable processes in organic synthesis. The use of highly efficient Smiles rearrangement to accomplish switchable enantioselec

Design and synthesis of new 8-anilide theophylline derivatives as bronchodilators and antibacterial agents

Theophylline derivatives have long been recognized as potent bronchodilators for the relief of acute asthma. Recently, it was found that bacterial infection has a role in asthma pathogenesis. The present work involves the design and synthesis of 8-substituted theophylline derivatives as bronchodilators and antibacterial agents. The chemical structures of these compounds were elucidated by IR, 1H-NMR, mass spectrometry, and elemental analyses. The bronchodilator activity was evaluated using acetylcholine-induced bronchospasm in guinea pigs, and most of the compounds showed significant anti-bronchoconstrictive activity in comparison with standard aminophylline. In addition, the antibacterial activity of all the target compounds was investigated in vitro against Gram-positive and Gram-negative bacteria using ampicillin as a reference drug. Results showed that some of the tested compounds possessed significant antibacterial activity. A pharmacophore model was computed to obtain useful insight into the essential structural features of bronchodilator activity. A structure activity relationship was also discussed.