943234-76-2Relevant academic research and scientific papers
A simple synthesis of the metabotropic receptor ligand (2S)-α-(hydroxymethyl)-glutamic acid and its Fmoc protected derivatives
Yiotakis, Athanasios,Magriotis, Plato A.,Vassiliou, Stamatia
, p. 873 - 877 (2007)
The highly enantioselective synthesis of (2S)-α-(hydroxymethyl)-glutamic acid 2, a potent metabotropic receptor ligand, was accomplished using the improved Schoellkopf methodology for the construction of quaternary α-amino acids and β-lactams. This was converted to a derivative suitably protected for direct use in Fmoc solid phase peptide synthesis.
