943338-77-0Relevant articles and documents
Design, synthesis and evaluation of cinnamic acid hybrids as multi-target-directed agents for the treatment of Alzheimer's disease
Wang, Keren,Shi, Jian,Zhou, Yi,He, Ying,Mi, Jing,Yang, Jing,Liu, Shuang,Tang, Xiangcheng,Liu, Wenmin,Tan, Zhenghuai,Sang, Zhipei
, (2021/05/03)
Herein, combining 1,2,3,4-tetrahydroisoquinoline and benzylpiperidine groups into cinnamic acid derivatives, a series of novel cinnamic acid hybrids was rationally designed, synthesized and evaluated by the multi-target-directed ligands (MTDLs) strategy.
Palladium(II)-Catalysed Aminocarbonylation of Terminal Alkynes for the Synthesis of 2-Ynamides: Addressing the Challenges of Solvents and Gas Mixtures
Hughes, N. Louise,Brown, Clare L.,Irwin, Andrew A.,Cao, Qun,Muldoon, Mark J.
, p. 675 - 680 (2017/03/01)
2-Ynamides can be synthesised through PdIIcatalysed oxidative carbonylation, utilising low catalyst loadings. A variety of alkynes and amines can be used to afford 2-ynamides in high yields, whilst overcoming the drawbacks associated with previ
Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions
Huang, Hanchu,Zhang, Guojin,Chen, Yiyun
, p. 7872 - 7876 (2015/06/30)
A combination of hypervalent iodine(III) reagents (HIR) and photoredox catalysis with visible light has enabled chemoselective decarboxylative ynonylation to construct ynones, ynamides, and ynoates. This ynonylation occurs effectively under mild reaction conditions at room temperature and on substrates with various sensitive and reactive functional groups. The reaction represents the first HIR/photoredox dual catalysis to form acyl radicals from α-ketoacids, followed by an unprecedented acyl radical addition to HIR-bound alkynes. Its efficient construction of an mGlu5 receptor inhibitor under neutral aqueous conditions suggests future visible-light-induced biological applications.
Palladium-catalyzed oxidative aminocarbonylation by decarboxylative coupling: Synthesis of alkynyl amides
Hwang, Jinil,Choi, Jinseop,Park, Kyungho,Kim, Wonyoung,Song, Kwang Ho,Lee, Sunwoo
, p. 2235 - 2243 (2015/04/14)
Alkynyl amides were synthesized from a palladium-catalyzed coupling reaction of alkynyl carboxylic acids and amines under carbon monoxide. The reaction was conducted with palladium(II) acetate (5 mol-%) and silver(I) oxide (1.0 equiv.) in acetonitrile at 80 °C for 1 h. This method provides good to moderate product yields and good functional group tolerance towards ketone, ester, and nitrile groups.
Palladium-N-heterocyclic carbene (NHC)-catalyzed synthesis of 2-ynamides via oxidative aminocarbonylation of alkynes with amines
Zhang, Chunyan,Liu, Jianhua,Xia, Chungu
, p. 4750 - 4754 (2015/10/05)
A series of palladium-NHC complexes was prepared and their catalytic activity in the oxidative aminocarbonylation of alkynes with amines has been developed using oxygen as the benign oxidant, leading to an efficient approach toward the formation of a wide
Oxidative aminocarbonylation of terminal alkynes for the synthesis of alk-2-ynamides by using palladium-on-carbon as efficient, heterogeneous, phosphine-free, and reusable catalyst
Gadge, Sandip T.,Khedkar, Mayur V.,Lanke, Satish R.,Bhanage, Bhalchandra M.
supporting information; experimental part, p. 2049 - 2056 (2012/09/22)
Palladium-on-carbon (Pd/C)-catalyzed oxidative aminocarbonylations of alk-1-ynes with secondary amines provide the corresponding alk-2-ynamides in a good to excellent yields. This new methodology is applicable for the synthesis of a wide range of biologically active alk-2-ynamide derivatives. The developed protocol avoids the use of phosphine ligands, with an additional advantage of palladium catalyst recovery and reuse for up to four consecutive cycles. Copyright
SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS
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Page/Page column 36; 38, (2009/04/24)
The present invention relates to substituted propiolic acid amides, to methods for the production thereof, to medicaments containing these compounds and to the use thereof for producing medicaments.
