943410-47-7Relevant academic research and scientific papers
A concise approach to anthraquinone-xanthone heterodimers
Holmbo, Stephen D.,Pronin, Sergey V.
supporting information, p. 5065 - 5068 (2018/04/24)
A synthetic approach to anthraquinone-xanthone heterodimers is described. The route to the pentacyclic core features an efficient assembly of a benzocycloheptenone via a new intramolecular oxidative arylation of an enol ether and a Hauser-Kraus annulation-aldol reaction sequence to access the characteristic bicyclo[3.2.2]nonene motif. Acremoxanthone A is synthesized in 10 steps from commercially available material to demonstrate the application of this approach.
