943418-72-2Relevant academic research and scientific papers
Synthesis and antibacterial activities of para-alkoxy phenyl-β- ketoaldehyde derivatives
Liu, Jinbing,Wu, Fengyan,Song, Huacan,Wang, Zhihou,Zhao, Liangzhong
, p. 4228 - 4238 (2013/09/02)
A series of para-alkoxy phenyl-β-ketoaldehyde derivatives were synthesized and evaluated for antimicrobial activities. Preliminary results showed that some compounds had moderate antibacterial activities, especially, 3-(4-methoxyphenyl)-3-oxopropanal O-methyl oxime (4) showed more potent antibacterial activity against Staphylococcus aureus and resistant Helicobacter pylori than the other compounds. Compound 4 showed more active antibacterial activities against methicillin-resistant S. aureus than Houttuynin and levofloxacin. Compound 4 was also investigated and its antibacterial activities against the strains clinical separated of Staphylococcus aureus. The preliminary structure-activity relationships were obtained. The maximum tolerance dose value for acute toxicity of compound 4 was 5,000 mg/kg. It indicated that compound 4 should be safe in clinical treatment. Graphical Abstract: A series of para-alkoxy phenyl-β-ketoaldehyde derivatives were designed, synthesized and evaluated for antimicrobial activities. 3-(4-Methoxyphenyl)-3-oxopropanal O-methyl oxime (4) showed more potent antibacterial activities against Staphylococcus aureus and resistant Hp than the other compounds. The maximum tolerance dose values for acute toxicity of compound 4 was 5,000 mg/kg. It indicated that compound 4 should be safe in clinical treatment. [Figure not available: see fulltext.]
