943447-75-4Relevant academic research and scientific papers
5-Arylidene-4-thiazolidinone derivatives active as antidegenerative agents on human chondrocyte cultures
Panico, Annamaria,MacCari, Rosanna,Cardile, Venera,Crascí, Lucia,Ronsisvalle, Simone,Ottanà, Rosaria
, p. 84 - 90 (2013/04/24)
5-Arylidene-2-oxo-4-thiazolidinones and 2-phenylimino analogues were evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1β and for their inhibitory capability against matrix metalloproteinase- 13. Our results indicated that 5-arylidene-4-thiazolidinone derivatives 1-9 exhibit antidegenerative activity and could block multiple cartilage destruction during the osteoarthritic process. Out of the selected compounds, (5-arylidene- 2,4-dioxothiazolidin-3-yl)acetic acids 7-9 showed significant effectiveness in reducing NO release and restoring normal levels of GAGs in chondrocytes treated with IL-1β. Moreover, benzoic acids 1, 5 and 6 proved to be effective MMP-13 inhibitors and were able to restore normal levels of GAGs.
5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases
Maccari, Rosanna,Paoli, Paolo,Ottana, Rosaria,Jacomelli, Michela,Ciurleo, Rosella,Manao, Giampaolo,Steindl, Theodora,Langer, Thierry,Vigorita, Maria Gabriella,Camici, Guido
, p. 5137 - 5149 (2008/03/15)
4-(5-Arylidene-2,4-dioxothiazolidin-3-yl)methylbenzoic acids (2) were synthesized and evaluated in vitro as inhibitors of PTP1B and LMW-PTP, two protein tyrosine phosphatases (PTPs) which act as negative regulators of the metabolic and mitotic signalling
