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Usage

Uses

Used in Over-the-Counter Products:
Benzocaine is used as a local anesthetic in various over-the-counter products such as toothache gels, throat sprays, and sunburn remedies. It provides temporary relief from pain and discomfort caused by minor injuries or irritations.
Used in Medical Procedures:
Benzocaine is also used in medical procedures such as catheter insertion, circumcision, and endoscopy. It helps to numb the affected area, making the procedure more comfortable for the patient.
However, it is important to note that excessive use of benzocaine can lead to harmful side effects such as allergic reactions, breathing problems, and methemoglobinemia. Therefore, it is crucial to use benzocaine products as directed and to seek medical advice if any adverse reactions occur.

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors

Inhibitors of the flaviviral serine proteases, which are crucial for the replication of dengue and West-Nile virus, have attracted much attention over the last years. A dibasic 4-guanidinobenzoate was previously reported as inhibitor of the dengue protease with potency in the low-micromolar range. In the present study, this lead structure was modified with the intent to explore structure-activity relationships and obtain compounds with increased drug-likeness. Substitutions of the guanidine moieties, the aromatic rings, and the ester with other functionalities were evaluated. All changes were accompanied by a loss of inhibition, indicating that the 4-guanidinobenzoate scaffold is an essential element of this compound class. Further experiments indicate that the target recognition of the compounds involves the reversible formation of a covalent adduct.