943451-03-4Relevant academic research and scientific papers
Study on glycosylated prodrugs of toxoflavins for antibody-directed enzyme tumor therapy
Wang, Shusheng,Liu, Dan,Zhang, Xu,Li, Shengyu,Sun, Yongxu,Li, Jia,Zhou, Yifa,Zhang, Liping
, p. 1254 - 1260 (2007)
Eight novel toxoflavin glycosides, which are potential prodrugs in antibody directed enzyme prodrug therapy (ADEPT), were synthesized. The structures of all toxoflavin glycosides were characterized by 13C NMR spectroscopy, elemental analysis, and MS. Their enzymatic hydrolysis activities were tested against β-glucosidase (EC.3.2.1.21).
