94347-12-3

Basic information

• Product Name: N-((1,1-Dimethylethoxy)carbonyl)-O-(phenylmethyl)-L-serine
• CAS NO: 94347-12-3
• Molecular Formula: C₁₅H₂₁NO₅
• Molecular Weight: 295.335
• Mol File: 94347-12-3.mol

Chemical Properties

• CAS DataBase Reference: N-((1,1-Dimethylethoxy)carbonyl)-O-(phenylmethyl)-L-serine(CAS DataBase Reference)
• NIST Chemistry Reference: N-((1,1-Dimethylethoxy)carbonyl)-O-(phenylmethyl)-L-serine(94347-12-3)
• EPA Substance Registry System: N-((1,1-Dimethylethoxy)carbonyl)-O-(phenylmethyl)-L-serine(94347-12-3)

Safety Data

• Hazardous Substances Data: 94347-12-3(Hazardous Substances Data)

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 5445-44-3 O-benzylserine 
• 3850-40-6 N-Boc-DL-serine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 67389-46-2 2-amino-3-benzyloxy-N-tert-butoxycarbonyl-propionic acid methyl ester 
• 232614-87-8 2-amino-N-(2-benzyloxy-1-{N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl}ethyl)-2-methylpropionamide 
• 956112-08-6 C₁₉H₂₈N₂O₇ 

Relevant articles and documents

PYRROLOPYRROLONES ACTIVE AS KINASE INHIBITORS

Compounds represented by formula (I) wherein A, R1, R2, R3, and R4 are as defined in the specification, compositions thereof, and methods of use thereof.

SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS

The present invention relates to compounds of formula (I), wherein n is zero, 1, 2 or 3; R represents C 1-6 alkyl, C 1-6 alkoxy, hydroxy, halogen, cyano, trifluoromethyl SO 2 C 1-6 alkyl, NR. sup.a R b, NR a COR b or CONR a R b, where R a and R b are each H, C 1-4 alkyl, phenyl or trifluoromethyl; R. sup.1 represents phenyl optionally substituted by 1, 2 or 3 of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl,--O(CH 2) p O--(where p is 1 or 2) , halogen, cyano, nitro, trifluoromethyl, trimethylsilyl, OR a, SR. sup.a, SOR a, SO 2 R a, NR a R b, NR a COR b, NR a CO 2 R b, COR a, CO 2 R a or CONR a R. sup.b ; naphthyl; benzhydryl; or benyl, where the naphthyl group or each phenyl moiety of benzyl and benzhydryl may be substituted by C 1-6 alkyl, C 1-6 alkoxy, halogen or trifluoromethyl; R 2 represents hydogen, a substituent as defined for R 1 or heteroaryl selected from indazolyl, thienyl, furanyl, pyridyl, thiazolyl, tetrazolyl and quinolinyl; wherein each heteroaryl may be substituted by C 1-6 alkyl, C 1-6 alkoxy, halogen or trifluoromethyl; R 3 and R 4 are each H or C 1-6 alkyl or R 3 and R 4 together are linked so as to form a C 1-3 alkylene chain; R 5 represents H, C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, phenylC. sub.1-4 alkyl, CO 2 R a, CONR a R b, SOR a or SO 2 R a, wherein the phenyl moiety may be substituted by C. sub.1-6 alkyl, C 1-6 alkoxy, halogen or trifluoromethyl; X and Y are each H, or together represents =O; and Z represents a bond, O, S, SO, SO 2, NR 6, or--(CR 6 R 6)--where R 6 is H or C. sub.1-6 alkyl; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia. STR1