943521-74-2Relevant academic research and scientific papers
Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity
Tran, Joe A.,Tucci, Fabio C.,Jiang, Wanlong,Marinkovic, Dragan,Chen, Caroline W.,Arellano, Melissa,Markison, Stacy,Fleck, Beth A.,Wen, Jenny,White, Nicole S.,Pontillo, Joseph,Saunders, John,Marks, Daniel,Hoare, Sam R.,Madan, Ajay,Foster, Alan C.,Chen, Chen
, p. 5166 - 5176 (2008/03/13)
A series of pyrrolidinones derived from phenylalanines were synthesized as potent antagonists of the human melanocortin-4 receptor. These compounds showed high potencies and selectivities, and several of them had good oral bioavailabilities. In addition,
