943524-18-3

Basic information

• Product Name: 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-7-fluoroindole
• Synonyms: 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-7-fluoroindole
• CAS NO: 943524-18-3
• Molecular Weight: 489.662
• Mol File: 943524-18-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-7-fluoroindole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-7-fluoroindole(943524-18-3)
• EPA Substance Registry System: 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-7-fluoroindole(943524-18-3)

Safety Data

• Hazardous Substances Data: 943524-18-3(Hazardous Substances Data)

Upstream product

• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 387-44-0 7-fluoro-1H-indole 
• 943524-12-7 1-[2'-deoxy-3',5'-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-7-fluoroindole 
• 943524-13-8 1-(2'-deoxy-β-D-erythro-pentofuranosyl)-7-fluoroindole 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 943524-20-7 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-7-fluoroindole 

Relevant articles and documents

Synthesis of fluorinated indoles as RNA analogues

Nucleoside analogues are chemical means to investigate hydrogen bonds, base stacking, and solvation as the three predominant forces that are responsible for the stability of secondary structure of nucleic acids. To obtain deeper insight into the contributions of these interactions to RNA stability apart from the ones exerted by the predominant nucleosides we decided to synthesize some novel nucleic acid analogues where the nucleobases are replaced by fluoroindoles. Fluorinated indoles can be compared to fluorinated benzimidazoles to determine the role of nitrogen in five membered ring system. The synthesis of fluoroindole ribonucleosides is described here. Copyright Taylor & Francis Group, LLC.