943528-10-7Relevant academic research and scientific papers
Application of asymmetric hydrogenation in synthesis of Trelagliptin intermediate
-
, (2018/09/21)
The invention provides a synthetic method of a compound Trelagliptin intermediate represented by a formula (1) (shown in the description). The synthetic method comprises the steps of carrying out a series of reactions on a starting material, namely a compound represented by a formula (1) (shown in the description) so as to finally obtain the compound by the formula (1), namely the Trelagliptin intermediate. Compared with a synthetic method of the Trelagliptin intermediate which comprises more synthetic steps and has a complex synthetic process in the prior art, the synthetic method provided by the invention is simple, feasible, relatively low in cost, relatively high in yield, relatively good in product quality and suitable for large-scale industrial production.
A kind of optical active pharmaceutical process for the preparation of intermediates
-
Paragraph 0059; 0060, (2016/10/17)
The invention relates to a preparation method of an optical active compound, represented by formula I, or a hydrochloride of the optical active compound by taking a compound with optical activity as a starting material. Raw materials of the preparation method are cheap and easily available; no splitting is needed; the whole technological operation is simple and convenient; cost is low; pollution on environment is less; and the preparation method is suitable for industrialized production. In the formula I, n is 1 or 2 or 3.
METHOD FOR PRODUCING 3-AMINOPIPERIDINE DIASTEREOMER
-
Page/Page column 4-5, (2008/06/13)
A method for increasing the enantiomeric purity of a desired enantiomer of 3- aminopiperidine comprising: providing a composition containing (i?)-3-arninopiperidine and (jS)-3-aminopiperidine; combining the composition with a resolving agent selected from
