943542-73-2

Upstream product

• 113503-90-5 2-hydroxy-4-oxo-4-p-tolylbut-2-enoic acid ethyl ester 
• 5814-37-9 ethyl-4-(4-methylphenyl)-2,4-dioxobutyrate 
• 1381932-38-2 C₁₅H₁₇NO₆ 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 122-00-9 para-methylacetophenone 
• 95-92-1 oxalic acid diethyl ester 
• 623-73-4 diazoacetic acid ethyl ester 
• 622-97-9 1-ethenyl-4-methylbenzene 

Downstream Products

• 724743-26-4 C₁₁H₁₂N₂O 
• 1257427-47-6 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-p-tolyl-1H-pyrazole-5-carboxylic acid 
• 1357157-71-1 ethyl 1-(2-bromoethyl)-3-p-tolyl-1H-pyrazole-5-carboxylate 
• 1357157-58-4 2-(4-fluorobenzylthio)-1-(2-((1-(2-(diethylamino)-ethyl)-3-p-tolyl-1H-pyrazol-5-yl)methoxy)ethyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one 
• 1357158-12-3 2-((1-(2-(diethylamino)ethyl)-3-p-tolyl-1H-pyrazol-5-yl)methoxy)ethyl 4-methylbenzenesulfonate 
• 1357158-07-6 2-((1-(2-(diethylamino)ethyl)-3-p-tolyl-1H-pyrazol-5-yl)methoxy)ethanol 
• 1357158-02-1 tert-butyl 2-((1-(2-(diethylamino)ethyl)-3-p-tolyl-1H-pyrazol-5-yl)methoxy)acetate 
• 1357157-98-2 ethyl 2-((1-(2-(diethylamino)ethyl)-3-p-tolyl-1H-pyrazol-5-yl)methoxy)acetate 
• 1357157-91-5 (1-(2-(diethylamino)ethyl)-3-p-tolyl-1H-pyrazol-5-yl)methanol 
• 1357157-78-8 ethyl 1-(2-(diethylamino)ethyl)-3-p-tolyl-1H-pyrazole-5-carboxylate 
• 1316754-42-3 C₂₄H₂₉N₅O 
• 46413-67-6 3-(4-methylphenyl)-1H-pyrazole-5-carboxylic acid 

Relevant academic research and scientific papers

One-pot synthesis of pyrazole-5-carboxylates by cyclization of hydrazone 1,4-dianions with diethyl oxalate

The cyclization of hydrazone dianions with diethyl oxalate afforded pyrazole-5-carboxylates.

Design, synthesis and anti-HIV evaluation of 5-alkyl- 6-(benzo[d][1,3]dioxol-5-alkyl)-2-mercaptopyrimidin-4(3H)-ones as potent HIV-1 NNRTIs

In order to discover and develop the new HIV-1 NNRTIs, a series of 5-alkyl-6-(benzo[d][1,3]dioxol-5-ylalkyl)-2-mercaptopyrimidin-4(3H)-ones was synthesized and screened for their in vitro cytotoxicity against HIV-1. Most of the compounds we synthetized sh

The First Example of Azole-Fused Cyclic Anhydride Reacting in the Castagnoli-Cushman Way

Pyrazole-fused cyclic anhydrides have been employed for the first time as the Castagnoli-Cushman reaction partners to produce hitherto unknown 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5- a ]pyrazine-7-carboxylates in remarkably convenient and speedy fashion. At

1. 3, 5 - tri-substituted pyrazole compound and its preparation method and application

The invention discloses 1,3,5-trisubstituted pyrazole compounds, and a preparation method and application thereof. The structure of the compounds is shown as a general formula (I), and in the general formula (I), R1 is hydrogen, halogens, methyl or triflu

On water synthesis of N-unsubstituted pyrazoles: Semicarbazide hydrochloride as an alternative to hydrazine for preparation of pyrazole-3-carboxylate derivatives and 3,5-disubstituted pyrazoles

A green, simple and highly efficient method for the synthesis of pyrazole-3-carboxylates and 3,5-disubstituted pyrazoles by cyclization of 4-aryl(hetaryl, alkyl)-2,4-diketoesters and 1,3-diketones with semicarbazide hydrochloride under on water conditions has been developed. This method also does not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals.

Cascade regioselective synthesis of pyrazoles from nitroallylic acetates and N-tosyl hydrazine

A simple, practical, and regioselective synthetic protocol for the formation of pyrazoles was developed. Unlike all other previously reported reactions of nitroallylic acetates, this process was initiated by a S N2 reaction at the electrophilic γ site. A plausible mechanism for the cascade SN2-Michael synthesis is proposed.

Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4- phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives

A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5- carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents.

Design and synthesis of novel pyrazole-based Lp-PLA2 inhibitors

A series of novel pyrazole-based lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors have been designed and synthetized by a variety of acetophenones via a 10-step convergent approach. The synthetic approach is carefully opt

Synthesis and cytotoxicity evaluation of 1-[3-(9H-carbazol-4-yloxy)-2- hydroxypropyl]-3-aryl-1H-pyrazole-5-carboxylic acid derivatives

Several novel molecules, 1-(3′-(9H-carbazol-4-yloxy)-2′- hydroxypropyl)-3-aryl-1H-pyrazole-5-carboxylic acid derivatives 3a-g were synthesized and screened to evaluate their cytotoxicity against cancer cells in vitro. The compounds 3a-g has been prepared by the reaction of ethyl 3-aryl-1H-pyrazole-5-carboxylate with 4-oxiranylmethoxy-9H-carbazole in moderate to excellent yields. The cytotoxicity of synthesized compounds was evaluated by a SRB (sulforhodamine B) assay against cancer cell such as SK-N-SH human neuroblastoma (NB), human A549 lung carcinoma, human breast cancer MCF-7 cell lines. The results showed that seven compounds can suppress SK-N-SH tumor cancer cell growth. Among them, compound 3d was the most effective small molecule in inhibiting SK-N-SH cell growth.

Synthesis of pyrazole-3-carboxylates and pyrazole-1,5-dicarboxylates by one-pot cyclization of hydrazone dianions with diethyl oxalate

The one-pot cyclization of hydrazone dianions with diethyl oxalate allows a convenient synthesis of pyrazole-3-carboxylates and pyrazole-1,5-dicarboxylates.