943545-10-6Relevant academic research and scientific papers
Eight-step synthesis of routiennocin
Matsumotoa, Kenji,Kozmina, Sergey A.
supporting information; experimental part, p. 557 - 560 (2009/04/11)
Routiennocin is a member of a family of polycyclic pyrrole ether antibiotics that simultaneously uncouple oxidative phosphorylation and inhibit ATPase as a result of selective complexation of divalent metal ions. We describe a concise synthesis of routien
A sequential two-component etherification/oxa-conjugate addition reaction: Asymmetric synthesis of (+)-leucascandrolide A macrolactone
Evans, P. Andrew,Andrews, William J.
supporting information; experimental part, p. 5426 - 5429 (2009/03/12)
A smooth operator: The asymmetric synthesis of the macrolactone of (+)-leucascandrolide A (see structure) has been accomplished through a convergent route (longest linear sequence of 14 steps) in 20% overall yield. The assembly of the 1,5-bis(tetrahydropyran) core in a single operation provides the most concise synthetic approach developed to date. (Chemical Equation Presented)
