943593-94-0Relevant academic research and scientific papers
A novel indole synthesis via conjugate addition of pyrrolidine to o-nitrophenylacetylenes
Tokuyama, Hidetoshi,Makido, Takaki,Han-ya, Yuki,Fukuyama, Tohru
, p. 191 - 197 (2007)
A novel indole synthesis reaction by conjugate addition of pyrrolidine to o-nitrophenylacetylenes and subsequent reductive cyclization of o-nitroarylenamines was developed.
An annulative approach to highly substituted indoles: Unusual effect of phenolic additives on the success of the arylation of ketone enolates
Rutherford, Jennifer L.,Rainka, Matthew P.,Buchwald, Stephen L.
, p. 15168 - 15169 (2007/10/03)
A novel palladium-catalyzed arylation of ketone enolates with o-nitrohaloarenes was achieved through the addition of phenol additives. The mild reaction conditions employed allowed for the inclusion of a wide variety of functional groups in both substrates to be tolerated. The products of this reaction were then readily reductively cyclized to give highly substituted indoles in moderate to excellent overall yields. Copyright
