94360-03-9

Upstream product

• 3300-67-2 3-(2-chlorophenyl)-1-phenylpropenone 
• 109-77-3 malononitrile 
• 22966-11-6 (2E)-3-(2-chlorophenyl)-1-phenylprop-2-en-1-one 

Downstream Products

• 94360-26-6 2-Bromo-4-(2-chloro-phenyl)-6-phenyl-nicotinonitrile 
• 94360-64-2 4-(2-Chloro-phenyl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 94360-12-0 2-Bromo-2-[1-(2-chloro-phenyl)-3-oxo-3-phenyl-propyl]-malononitrile 
• 1220704-87-9 (S)-2-(1-(2-chlorophenyl)-3-oxo-3-phenylpropyl)malononitrile 
• 3300-69-4 2-(2-Chloro-phenyl)-4-oxo-4-phenyl-butyric acid methyl ester 
• 94360-85-7 3-Amino-4-(2-chloro-phenyl)-6-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid propyl ester 
• 94360-84-6 3-Amino-4-(2-chloro-phenyl)-6-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 94360-83-5 3-Amino-4-(2-chloro-phenyl)-6-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid methyl ester 
• 94360-71-1 3-Amino-4-(2-chloro-phenyl)-6-phenyl-thieno[2,3-b]pyridine-2-carbonitrile 
• 94360-55-1 cis-1-benzoyl-2-(2-chlorophenyl)-3,3-dicyanocyclopropane 

Relevant academic research and scientific papers

Stereoselective reductive radical cyclization of ketonitriles catalyzed by Cp2TiCl2 in the presence of chlorosilane and zinc

Reductive radical cyclization of ketonitriles was catalyzed by Cp2TiCl2 in the presence of Me3SiCl, zinc powder and imidazole, giving the 2-amino-3-cyano-2-cyclopenten-1-ols in moderate to good yields with high trans selec

Conjugate addition of malononitrile on chalcone: Biocatalytic [Formula presented] bond formation

An efficient, cost effective and environmentally friendly protocol has been developed for the Michael addition of malononitrile on 1,3-diaryl-2-propen-1-ones (Chalcones) using very cheaper, easily available natural catalyst, baker's yeast. The whole cells of yeast excellently worked in nonaqueous medium, ethanol without decrease in catalytic activity.

One-Pot Quinine-Catalyzed Synthesis of α-Chiral γ-Keto Esters: Enantioenriched Precursors of cis-α,γ-Substituted-γ-Butyrolactones

A highly enantioselective one-pot synthesis of important building blocks, α-chiral γ-keto esters, has been developed by combining a quinine-catalyzed Michael addition of malononitrile to trans-enones followed by magnesium monoperoxyphthalate (MMPP) oxidat

An active and selective heterogeneous catalytic system for Michael addition

Potassium fluoride doped natural zeolite was found to be an efficient and selective solid base catalyst for 1,4-Michael addition. The catalyst is easily prepared and the workup procedure simplified by simple filtration. All products were obtained in high

Back to natural cinchona alkaloids: Highly enantioselective Michael addition of malononitrile to enones

An efficient and convenient highly enantioselective Michael addition of malononitrile to enones has been developed by using quinine as the organocatalyst. The adducts were isolated in excellent yield and high asymmetric induction (up to 95% ee). An easy r

A novel tandem reaction of chalcone with malononitrile or ethylcyanoacetate promoted by samarium (III) iodide and followed by samarium (II) iodide

Michael additions of active methylene compounds (for example: malononitrile, ethylcyanoacetate) to chalcones promoted by Sm3 gave 1,4-adducts which, after intramolecular coupling reactions induced by Sm2, furnished fine yields of cyc

A convenient synthesis of (3-oxo-1,3-diaryl) propylpropanedinitrile catalyzed by KF-alumina

A series of (3-oxo-1,3-diaryl) propylpropanedinitriles were synthesized by Michael addition reaction of chalcones and malononitriles in the presence of potassium fluoride on alumina.

CYCLIZATION OF NITRILES. IX. SYNTHESES BASED ON 2-ARYL-3-AROYL-1,1-DICYANOPROPANES

2-Aryl-3-aroyl-1,1-dicyanopropanes and 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes were synthesized from chalcones and malononitrile and were converted into 4,6-diaryl-2-bromo-3-cyanopyridines and 3-cyano-2(1H)-pyridinethiones.The 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes proved convenient intermediates for the production of the corresponding cyclopropanes and other compounds.By their reaction with urea a new method was developed for the production of substituted 3-cyano-2(1H)-pyridinethiones.The 2-bromo-3-cyanopyridines contain a mobile bromine atom readily exchanged for the various nucleophilic residues of alcohols and amines and for iodide, and cyano and thiocyanato groups.The 3-cyano-2(1H)-pyridinethiones were used in the synthesis of 3-aminothienopyridines through the isolated 2-Z-methylthio-3-cyanopyridines.