943654-38-4

Basic information

• Product Name: (S)-2-Indol-1-yl-propionic acid
• Synonyms: (S)-2-Indol-1-yl-propionic acid
• CAS NO: 943654-38-4
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.21054
• Mol File: 943654-38-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-Indol-1-yl-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Indol-1-yl-propionic acid(943654-38-4)
• EPA Substance Registry System: (S)-2-Indol-1-yl-propionic acid(943654-38-4)

Safety Data

• Hazardous Substances Data: 943654-38-4(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 598-72-1 2-Bromopropionic acid 
• 77992-71-3 (R,S)-2-(indol-2-yl)propionic acid ethyl ester 
• 32644-15-8 (S)-2-bromopropanoic acid 
• 16982-67-5 sodium salt of indole 

Relevant articles and documents

Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach

Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common commercial material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.

Nonenzymatic, enantioconvergent dynamic kinetic resolution (DKR) of racemic 2-(1H-pyrrol-1-yl)alkanoic acids as α-amino acid equivalents

We report an effective dynamic kinetic resolution (DKR) system of racemic 2-(1H-pyrrol-1-yl)alkanoic acids, which consists of a rapid racemization step via an activating substrate and an enantio-discriminating step via catalytic esterification. The combination of pivalic anhydride as an activating agent, bis(α-naphthyl)methanol as an achiral alcohol, (R)-BTM as a chiral acyl-transfer catalyst, and Hunig's base converted racemic 2-(1H-pyrrol-1-yl)alkanoic acids to the corresponding chiral carboxylates, which can be transformed into chiral α-amino acid derivatives with maintained high enantiopurity.