943749-33-5Relevant academic research and scientific papers
A Ramberg-Baecklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212
Robinson, James E.,Taylor, Richard J. K.
, p. 1617 - 1619 (2008/02/08)
A concise route to combretastatin A-4, a potent inhibitor of tubulin polymerisation, using a Ramberg-Baecklund reaction to form the key (Z)-stilbene unit has been developed; this Ramberg-Baecklund approach has also been extended to prepare the (E)-stilbene DMU-212, which also possesses interesting growth inhibitory properties. The Royal Society of Chemistry.
