943753-31-9Relevant academic research and scientific papers
Synthesis of chemical-biology tools enabling in vivo imaging and analysis of epigallocatechin gallate
Asakawa, Tomohiro,Yoshida, Atsushi,Hirooka, Yasuo,Suzuki, Takashi,Itoh, Kunihiko,Shimizu, Kosuke,Oku, Naoto,Furuta, Takumi,Wakimoto, Toshiyuki,Inai, Makoto,Kan, Toshiyuki
, p. 218 - 242 (2017/03/14)
(-)-Epigallocatechin gallate (EGCg) has multiple bioactivities, and imaging/analytical tools are required for drug development studies. Here we present full details of our synthetic studies aimed at providing building blocks for development of such tools,
Efficient synthesis of optically active gallocatechin-3-gallate derivatives via 6-endo-cyclization
Hirooka, Yasuo,Nitta, Mariko,Furuta, Takumi,Kan, Toshiyuki
experimental part, p. 3234 - 3238 (2009/06/18)
Optically active dihydrobenzopyran derivatives are synthesized by 6-endo cyclization of corresponding epoxy-phenol, which is readily derived from the enantioselective epoxidation of 1,3-diarylpropene. Synthetic dihydrobenzopyrans are converted into (-)-5,7-dideoxy-gallocatechin gallate as well as (-)-5,7-dideoxy-epigallocatechin derivative. Georg Thieme Verlag Stuttgart.
Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activity
Furuta, Takumi,Hirooka, Yasuo,Abe, Ayako,Sugata, Yusuke,Ueda, Mitsuru,Murakami, Kouki,Suzuki, Takashi,Tanaka, Kiyoshi,Kan, Toshiyuki
, p. 3095 - 3098 (2008/12/21)
Dideoxy-epigallocatechin gallate (DO-EGCG) (2), a simplified analog of naturally occurring EGCG (1), was efficiently prepared by directly introducing a ketone group at C3 and successive reduction to the sec-alcohol with 2,3-cis stereochemistry. Compound 2 showed potent anti-influenza virus activity, indicating that the hydroxyl substituents on the A-ring are not crucial for anti-influenza virus activity.
