94385-96-3Relevant academic research and scientific papers
Total synthesis and structure activity relationship studies of phelligridins C and D, and phellifuropyranone A
Ohyoshi, Takayuki,Mitsugi, Keisuke,Ichimura, Fumitaka,Higuma, Tatsuya,Yoshida, Masahito,Kigoshi, Hideo
, p. 1540 - 1551 (2020/12/29)
α-Pyrone polyphenols, phelligridins C and D (meshimakobnols B and A), and phellifuropyranone A, isolated from a Japanese mushroom, are growth inhibitors of cancer cells. Herein, we report full details of the total synthesis of phelligridins C and D. The key reactions of the synthetic pathways were Pd catalyzed cross-coupling and aldol-type condensation. This strategy also enabled the total synthesis of phellifuropyranone A and artificial analogs of phelligridins. Subsequent biological evaluation of these compounds clarified that the whole skeleton of phelligridin C and the catechol group of the left hand side are essential for the cytotoxicity.
