943918-51-2Relevant academic research and scientific papers
Design, synthesis, and in vitro evaluation of cytotoxic activity of new substituted 1,4-benzoquinones and hydroquinones
Chaaban, Ibrahim,El-Khawass, El-Sayeda,Mahran, Mona,El-Sayed, Ola,El-Saidi, Hassan,Aboul-Enen, Hassan
, p. 49 - 77 (2008/12/21)
A new series of p-benzoquinones, hydroquinones, and quinol dimethyl ethers substituted by a pyrazole ring either directly or after an oxoethyl linker was synthesized and screened for in vitro cytotoxic activity. Compounds 8d, f, g, i, and 9c, f, and 13c exhibited broad-spectrum activity (GI50 MG-MID values 9.27-14.72 μM). With regard to sensitivity, compounds 8f and 9c, f have proved to possess a remarkable activity against leukemia tumor cell lines (GI50 = 3.43-5.03 μM). Indeed, compound 13c showed the highest activity profile against individual leukemia subpanel cell line SR (GI 50 = 0.91 μM).
