943967-10-0Relevant articles and documents
Robust polymeric nanoparticles for the delivery of aminoglycoside antibiotics using carboxymethyldextran-b-poly(ethyleneglycols) lightly grafted with n-dodecyl groups
Soliman, Ghareb M.,Szychowski, Janek,Hanessian, Stephen,Winnik, Franoise M.
, p. 4504 - 4514 (2010)
Aminoglycoside antibiotics are effective in the treatment of infections caused by aerobic Gram negative bacilli, but their widespread use is hampered by serious side effects that may be alleviated through the use of tailored delivery systems. Robust polyi
6-Hydroxy to 6?-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3′)-IIIa kinase
Hanessian, Stephen,Szychowski, Janek,Campos-Reales Pineda, Natalhie B.,Furtos, Alexandra,Keillor, Jeffrey W.
, p. 3221 - 3225 (2008/02/03)
Based on molecular modeling and available X-ray structure data on aminoglycosides complexed with a bacterial ribosomal surrogate or with a kinase, two analogues of paromomycin were prepared by tethering the 6-OH and the 6?-NH2 group with a five
Novel conjugates of polysaccharides and uses thereof
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Page/Page column 16-17; 1/3, (2008/06/13)
Novel conjugates composed of a saccharide-containing moiety (e.g., aminoglycosides) covalently linked to a moiety containing two or more basic amino acid residues (e.g., a polyarginine) and processes of preparing same are disclosed. Further disclosed are