943983-22-0Relevant articles and documents
Synthesis and aminomethylation of 2-isobutyl-3-and 4- diethoxyphosphorylmethylfurans
Pevzner
, p. 1063 - 1068 (2006)
Synthetic procedure for preparing 2-isobutyl-3-and 4-furancarboxylic acyl chlorides is developed. Reduction of these compounds with lithium alumohydride leads to corresponding alcohols which under treating with thionyl chloride in the presence of pyridine form chloromethyl derivatives. The latter compounds are phosphorylated with sodium diethyl phosphite under the Michaelis-Becker reaction conditions to give corresponding phosphonates. Reaction of compounds obtained with dimethyl(chloromethyl)amine proceeds at the free α-position of the furan ring and delivers aminophosphonates. These substances do not evolve dimethylamine even under the conditions of vacuum distillation (145-150°C, 1 mm Hg). Pleiades Publishing, Inc., 2006.
