943993-99-5

Upstream product

• 103-80-0 phenylacetyl chloride 
• 88-75-5 2-hydroxynitrobenzene 
• 37682-31-8 ethyl o-nitrophenoxyacetate 
• 103-82-2 phenylacetic acid 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 

Downstream Products

• 943994-12-5 6-(2-phenylacryloyl)-2H-1,4-benzoxazin-3(4H)-one 
• 1342235-17-9 6-(1-(3,5-dichlorophenyl)-4-phenyl-1H-pyrazol-3-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1253194-19-2 6-(4-phenylisoxazol-3-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1086390-31-9 1-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-2-phenyl-ethane-1,2-dione 
• 1342235-49-7 6-(2,4-diphenyl-1H-imidazol-5-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-51-1 6-(2-(2,4-dichlorophenyl)-4-phenyl-1H-imidazol-5-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-53-3 6-(4-phenyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-5-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-54-4 6-(2-(4-methoxyphenyl)-4-phenyl-1H-imidazol-5-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-55-5 6-(2-(4-fluorophenyl)-4-phenyl-1H-imidazol-5-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-56-6 6-(4-phenyl-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-imidazol-5-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1253194-12-5 C₂₃H₁₇N₃O₂ 
• 1342235-09-9 6-(1-(4-chlorophenyl)-4-phenyl-1H-pyrazol-3-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1342235-11-3 6-(1-(4-fluorophenyl)-4-phenyl-1H-pyrazol-3-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1253194-14-7 6-(1-(4-methoxyphenyl)-4-phenyl-1H-pyrazol-3-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one 

Relevant academic research and scientific papers

H3PO4/(CF3CO)2O mediated acylation followed by hurd-mori reaction: Synthesis of novel 1,2,3-thiadiazol derivatives

The synthesis of novel 1,2,3-thiadiazol derivatives containing 2H-benzo[b][1,4]oxazin-3(4H)-one moiety as one of the substituents has been reported. A combined application of H3PO4/(CF 3CO)2O mediated acylation followed by Hurd-Mori reaction has been explored to synthesize these compounds. The scope and limitation of this strategy along with the reaction mechanism of the key step is discussed.

Synthesis and pharmacological evaluations of novel 2H-benzo[b][1,4]oxazin- 3(4H)-one derivatives as a new class of anti-cancer agents

The synthesis of novel 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives has been carried out using trifluoroacetic anhydride/phosphoric acid mediated C-C bond forming reaction as a key step. This method does not require the use of environmentally harmful AlCl3 or moisture sensitive acid chloride. A number of compounds containing the benzooxazinone moiety attached to a five-membered central heterocyclic ring was synthesized and tested for their anti-cancer properties in vitro against three cell lines e.g. A549 (lung), DLD-1 (colorectal adenocarcinoma) and MV4-11 (acute myeloid leukemia). Some of them showed anti-cancer activities along with a number of reference compounds tested. Few of them showed promising anti-leukemic properties. A brief Structure-Activity-Relationship study within the series is presented. An imidazole derivative 9c containing benzene ring with a para-CF3 group at C-2 position was identified as a potent anti-leukemic agent.

FUSED HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.