944045-33-4Relevant academic research and scientific papers
A Porphyrin-Based Conjugated Polymer for Highly Efficient In Vitro and In Vivo Photothermal Therapy
Guo, Bing,Feng, Guangxue,Manghnani, Purnima Naresh,Cai, Xiaolei,Liu, Jie,Wu, Wenbo,Xu, Shidang,Cheng, Xiamin,Teh, Cathleen,Liu, Bin
, p. 6243 - 6254 (2016/12/07)
Conjugated polymers have been increasingly studied for photothermal therapy (PTT) because of their merits including large absorption coefficient, facile tuning of exciton energy dissipation through nonradiative decay, and good therapeutic efficacy. The high photothermal conversion efficiency (PCE) is the key to realize efficient PTT. Herein, a donor–acceptor (D–A) structured porphyrin-containing conjugated polymer (PorCP) is reported for efficient PTT in vitro and in vivo. The D–A structure introduces intramolecular charge transfer along the backbone, resulting in redshifted Q band, broadened absorption, and increased extinction coefficient as compared to the state-of-art porphyrin-based photothermal reagent. Through nanoencapsulation, the dense packing of a large number of PorCP molecules in a single nanoparticle (NP) leads to favorable nonradiative decay, good photostability, and high extinction coefficient of 4.23 × 104m?1 cm?1 at 800 nm based on porphyrin molar concentration and the highest PCE of 63.8% among conjugated polymer NPs. With the aid of coloaded fluorescent conjugated polymer, the cellular uptake and distribution of the PorCP in vitro can be clearly visualized, which also shows effective photothermal tumor ablation in vitro and in vivo. This research indicates a new design route of conjugated polymer-based photothermal therapeutic materials for potential personalized theranostic nanomedicine.
Amplified two-photon absorption in trans-A2B2- porphyrins bearing nitrophenylethynyl substituents
Nowak-Krol, Agnieszka,Wilson, Craig J.,Drobizhev, Mikhail,Kondratuk, Dmitry V.,Rebane, Aleksander,Anderson, Harry L.,Gryko, Daniel T.
, p. 3966 - 3972 (2013/02/25)
We show that peripheral nitro groups enhance the maximum two-photon absorption cross-section of trans-A2B2-porphyrins bearing two phenylethynyl substituents by more than one order of magnitude. Maximum values as high as 1000 GM result from realization of suitable conditions for effective resonance enhancement along with a lowering of the energy and intensification of the two-photon allowed transitions in the Soret region. Copyright
Probing flexibility in porphyrin-based molecular wires using double electron electron resonance
Lovett, Janet E.,Hoffmann, Markus,Cnossen, Arjen,Shutter, Alexander T. J.,Hogben, Hannah J.,Warren, John E.,Pascu, Sofia I.,Kay, Christopher W. M.,Timmel, Christiane R.,Anderson, Harry L.
supporting information; experimental part, p. 13852 - 13859 (2010/01/06)
A series of butadiyne-linked zinc porphyrin oligomers, with one, two, three, and four porphyrin units and lengths of up to 75 A, have been spin-labeled at both ends with stable nitroxide TEMPO radicals. The pulsed EPR technique of double electron electron
Single molecule conductance of porphyrin wires with ultralow attenuation
Sedghi, Gita,Sawada, Katsutoshi,Esdaile, Louisa J.,Hoffmann, Markus,Anderson, Harry L.,Bethell, Donald,Haiss, Wolfgang,Higgins, Simon J.,Nichols, Richard J.
supporting information; experimental part, p. 8582 - 8583 (2009/02/03)
A series of thioacetate-terminated butadiyne-linked porphyrin oligomers have been synthesized with one to three porphyrin repeat units. Single molecule electrical scanning tunneling microscopy measurements using the I(s) and I(t) methods were used to determine the molecule conductances for this series of oligomers. The molecular conductance shows an exponential falloff with sulfur-sulfur distance with a remarkably low attenuation factor of β = (0.04 ± 0.006) A-1. Copyright
